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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

ALTHIAZIDE\SPIRONOLACTONE: 322 Adverse Event Reports & Safety Profile

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322
Total FAERS Reports
7 (2.2%)
Deaths Reported
219
Hospitalizations
322
As Primary/Secondary Suspect
68
Life-Threatening
8
Disabilities

First Report: 20080401 · Latest Report: 20250625

What Are the Most Common ALTHIAZIDE\SPIRONOLACTONE Side Effects?

#1 Most Reported
Acute kidney injury
79 reports (24.5%)
#2 Most Reported
Hyponatraemia
68 reports (21.1%)
#3 Most Reported
Hyperkalaemia
62 reports (19.3%)

All ALTHIAZIDE\SPIRONOLACTONE Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Acute kidney injury 79 24.5% 2 33
Hyponatraemia 68 21.1% 0 66
Hyperkalaemia 62 19.3% 0 13
Lactic acidosis 51 15.8% 5 13
Fall 45 14.0% 0 37
Hypokalaemia 41 12.7% 4 31
Hypotension 28 8.7% 0 21
Cardio-respiratory arrest 17 5.3% 0 0
Hypoglycaemia 17 5.3% 0 3
Bradycardia 16 5.0% 0 4
Dehydration 16 5.0% 2 16
Inappropriate antidiuretic hormone secretion 16 5.0% 0 14
Rhabdomyolysis 16 5.0% 0 2
Sleep apnoea syndrome 16 5.0% 0 9
Anuria 14 4.4% 0 0
Coma 14 4.4% 1 12
Malaise 14 4.4% 1 7
General physical health deterioration 13 4.0% 5 9
Head injury 12 3.7% 0 4
Diarrhoea 11 3.4% 1 10

Who Reports ALTHIAZIDE\SPIRONOLACTONE Side Effects? Age & Gender Data

Gender: 70.8% female, 29.2% male. Average age: 73.6 years. Most reports from: FR. View detailed demographics →

Is ALTHIAZIDE\SPIRONOLACTONE Getting Safer? Reports by Year

YearReportsDeathsHosp.
2008 4 1 4
2009 1 0 1
2010 1 0 1
2011 4 0 2
2012 6 0 5
2013 2 0 2
2014 8 0 8
2015 19 0 18
2016 39 5 32
2017 36 0 15
2018 58 1 37
2019 24 0 7
2020 28 0 28
2021 12 0 4
2022 7 0 7
2023 22 0 18
2024 14 0 14
2025 5 0 5

View full timeline →

What Is ALTHIAZIDE\SPIRONOLACTONE Used For?

IndicationReports
Hypertension 201
Product used for unknown indication 73
Cardiac failure 8
Cardiac disorder 7
Suicide attempt 5

ALTHIAZIDE\SPIRONOLACTONE vs Alternatives: Which Is Safer?

ALTHIAZIDE\SPIRONOLACTONE vs ALUMINUM ALTHIAZIDE\SPIRONOLACTONE vs ALUMINUM HYDROXIDE ALTHIAZIDE\SPIRONOLACTONE vs ALUMINUM HYDROXIDE\DIMETHICONE\MAGNESIUM HYDROXIDE ALTHIAZIDE\SPIRONOLACTONE vs ALUMINUM HYDROXIDE\MAGNESIUM ALTHIAZIDE\SPIRONOLACTONE vs ALUMINUM HYDROXIDE\MAGNESIUM HYDROXIDE ALTHIAZIDE\SPIRONOLACTONE vs ALUMINUM ZIRCONIUM TRICHLOROHYDREX GLY ALTHIAZIDE\SPIRONOLACTONE vs ALVERINE\DIMETHICONE ALTHIAZIDE\SPIRONOLACTONE vs AMANTADINE ALTHIAZIDE\SPIRONOLACTONE vs AMBIEN ALTHIAZIDE\SPIRONOLACTONE vs AMBISOME

Official FDA Label for ALTHIAZIDE\SPIRONOLACTONE

Official prescribing information from the FDA-approved drug label.