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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

BUPIVACAINE\EPINEPHRINE: 174 Adverse Event Reports & Safety Profile

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174
Total FAERS Reports
5 (2.9%)
Deaths Reported
14
Hospitalizations
174
As Primary/Secondary Suspect
9
Life-Threatening
2
Disabilities

Active Ingredient: BUPIVACAINE HYDROCHLORIDE\EPINEPHRINE BITARTRATE ·

First Report: 19850701 · Latest Report: 20250127

What Are the Most Common BUPIVACAINE\EPINEPHRINE Side Effects?

#1 Most Reported
Drug ineffective
62 reports (35.6%)
#2 Most Reported
Haemorrhage
27 reports (15.5%)
#3 Most Reported
Toxicity to various agents
8 reports (4.6%)

All BUPIVACAINE\EPINEPHRINE Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Drug ineffective 62 35.6% 0 0
Haemorrhage 27 15.5% 0 0
Horner's syndrome 8 4.6% 0 1
Toxicity to various agents 8 4.6% 1 1
Anaphylactic reaction 7 4.0% 0 2
Heart rate increased 6 3.5% 0 0
Hypertension 6 3.5% 0 0
Seizure 6 3.5% 0 1
Anaesthetic complication 5 2.9% 1 1
Cardiac arrest 5 2.9% 0 0
Labelled drug-drug interaction medication error 5 2.9% 0 0

Who Reports BUPIVACAINE\EPINEPHRINE Side Effects? Age & Gender Data

Gender: 63.0% female, 37.0% male. Average age: 51.4 years. Most reports from: US. View detailed demographics →

Is BUPIVACAINE\EPINEPHRINE Getting Safer? Reports by Year

YearReportsDeathsHosp.
2013 2 0 1
2014 4 0 3
2015 12 0 1
2016 9 0 1
2017 4 0 0
2018 3 0 0
2019 9 0 1
2020 2 0 0
2021 3 0 0
2022 7 1 0
2023 2 0 0
2024 31 0 0
2025 2 2 0

View full timeline →

What Is BUPIVACAINE\EPINEPHRINE Used For?

IndicationReports
Local anaesthesia 48
Product used for unknown indication 22
Anaesthesia 12
Nerve block 12
Dental local anaesthesia 10
Spinal anaesthesia 6

BUPIVACAINE\EPINEPHRINE vs Alternatives: Which Is Safer?

BUPIVACAINE\EPINEPHRINE vs BUPIVACAINE\MELOXICAM BUPIVACAINE\EPINEPHRINE vs BUPRENORPHINE BUPIVACAINE\EPINEPHRINE vs BUPRENORPHINE\NALOXONE BUPIVACAINE\EPINEPHRINE vs BUPROPION BUPIVACAINE\EPINEPHRINE vs BUPROPION HYDROBROMIDE BUPIVACAINE\EPINEPHRINE vs BUPROPION\DEXTROMETHORPHAN HYDROBROMIDE BUPIVACAINE\EPINEPHRINE vs BUPROPION\NALTREXONE BUPIVACAINE\EPINEPHRINE vs BUROSUMAB BUPIVACAINE\EPINEPHRINE vs BUROSUMAB-TWZA BUPIVACAINE\EPINEPHRINE vs BUSPIRONE

Official FDA Label for BUPIVACAINE\EPINEPHRINE

Official prescribing information from the FDA-approved drug label.