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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

CARBIDOPA\LEVODOPA: 58,317 Adverse Event Reports & Safety Profile

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58,317
Total FAERS Reports
12,844 (22.0%)
Deaths Reported
25,836
Hospitalizations
58,317
As Primary/Secondary Suspect
899
Life-Threatening
704
Disabilities

First Report: 1976 · Latest Report: 20250925

What Are the Most Common CARBIDOPA\LEVODOPA Side Effects?

#1 Most Reported
Fall
7,132 reports (12.2%)
#2 Most Reported
Death
5,403 reports (9.3%)
#3 Most Reported
Dyskinesia
5,368 reports (9.2%)

All CARBIDOPA\LEVODOPA Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Fall 7,132 12.2% 657 4,897
Death 5,403 9.3% 5,395 1,012
Dyskinesia 5,368 9.2% 363 2,448
Tremor 3,689 6.3% 149 1,160
General physical health deterioration 3,636 6.2% 1,623 2,127
On and off phenomenon 3,509 6.0% 241 1,887
Hallucination 3,367 5.8% 289 1,777
Drug ineffective 3,205 5.5% 132 785
Parkinson's disease 3,140 5.4% 943 1,468
Device dislocation 2,937 5.0% 246 2,054
Weight decreased 2,772 4.8% 341 1,488
Gait disturbance 2,740 4.7% 154 1,263
Device issue 2,574 4.4% 193 1,560
Mobility decreased 2,392 4.1% 226 1,521
Pneumonia 2,361 4.1% 1,096 1,851
Stoma site discharge 2,332 4.0% 166 1,380
Freezing phenomenon 2,311 4.0% 131 1,110
Fatigue 2,180 3.7% 163 850
Urinary tract infection 2,151 3.7% 336 1,681
Asthenia 2,116 3.6% 320 1,117

Who Reports CARBIDOPA\LEVODOPA Side Effects? Age & Gender Data

Gender: 42.5% female, 57.5% male. Average age: 71.7 years. Most reports from: US. View detailed demographics →

Is CARBIDOPA\LEVODOPA Getting Safer? Reports by Year

YearReportsDeathsHosp.
2000 2 0 0
2001 26 0 18
2002 18 2 2
2003 1 1 1
2004 6 1 3
2005 9 0 3
2006 13 1 1
2007 10 0 4
2008 23 2 5
2009 46 28 23
2010 31 2 10
2011 46 6 24
2012 93 16 53
2013 111 17 58
2014 400 74 233
2015 1,974 384 1,008
2016 2,641 474 1,428
2017 3,805 676 1,950
2018 4,348 782 2,290
2019 4,383 921 2,378
2020 4,118 993 2,067
2021 4,009 1,030 1,924
2022 3,889 1,045 1,879
2023 3,630 1,012 1,949
2024 3,298 1,074 1,681
2025 1,628 598 790

View full timeline →

What Is CARBIDOPA\LEVODOPA Used For?

IndicationReports
Parkinson's disease 44,842
Product used for unknown indication 11,028
Parkinsonism 368
Tremor 162
On and off phenomenon 100
Dystonia 72
Multiple system atrophy 71
Dementia with lewy bodies 51
Dyskinesia 51
Restless legs syndrome 44

CARBIDOPA\LEVODOPA vs Alternatives: Which Is Safer?

CARBIDOPA\LEVODOPA vs CARBIMAZOLE CARBIDOPA\LEVODOPA vs CARBOCYSTEINE CARBIDOPA\LEVODOPA vs CARBOMER CARBIDOPA\LEVODOPA vs CARBON DIOXIDE CARBIDOPA\LEVODOPA vs CARBON MONOXIDE CARBIDOPA\LEVODOPA vs CARBOPLATIN CARBIDOPA\LEVODOPA vs CARBOPROST TROMETHAMINE CARBIDOPA\LEVODOPA vs CARBOXYMETHYLCELLULOSE CARBIDOPA\LEVODOPA vs CARBOXYMETHYLCELLULOSE\GLYCERIN CARBIDOPA\LEVODOPA vs CARBOXYMETHYLCELLULOSE\GLYCERIN\POLYSORBATE 80

Official FDA Label for CARBIDOPA\LEVODOPA

Official prescribing information from the FDA-approved drug label.