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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

CEFOPERAZONE\SULBACTAM: 797 Adverse Event Reports & Safety Profile

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797
Total FAERS Reports
131 (16.4%)
Deaths Reported
367
Hospitalizations
797
As Primary/Secondary Suspect
115
Life-Threatening
37
Disabilities

Active Ingredient: CEFOPERAZONE SODIUM\SULBACTAM SODIUM ·

First Report: 20030918 · Latest Report: 20250730

What Are the Most Common CEFOPERAZONE\SULBACTAM Side Effects?

#1 Most Reported
Off label use
155 reports (19.4%)
#2 Most Reported
Drug ineffective
88 reports (11.0%)
#3 Most Reported
Coagulopathy
62 reports (7.8%)

All CEFOPERAZONE\SULBACTAM Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Off label use 155 19.5% 20 65
Drug ineffective 88 11.0% 42 38
Coagulopathy 62 7.8% 4 40
Platelet count decreased 59 7.4% 3 23
Hepatic function abnormal 57 7.2% 4 10
Drug-induced liver injury 39 4.9% 3 14
Condition aggravated 38 4.8% 7 20
Pyrexia 34 4.3% 5 21
Diarrhoea 32 4.0% 3 19
Pruritus 31 3.9% 0 12
Rash 27 3.4% 2 10
Product use in unapproved indication 25 3.1% 2 9
Dyspnoea 24 3.0% 1 18
Pathogen resistance 24 3.0% 10 15
Haemoglobin decreased 23 2.9% 1 11
Hepatic enzyme increased 22 2.8% 1 6
Klebsiella infection 22 2.8% 9 15
Pneumonia 22 2.8% 8 14
Liver injury 20 2.5% 2 5
Prothrombin time prolonged 19 2.4% 2 8

Who Reports CEFOPERAZONE\SULBACTAM Side Effects? Age & Gender Data

Gender: 30.6% female, 69.4% male. Average age: 57.9 years. Most reports from: CN. View detailed demographics →

Is CEFOPERAZONE\SULBACTAM Getting Safer? Reports by Year

YearReportsDeathsHosp.
2003 1 0 1
2004 1 0 1
2006 1 0 0
2007 6 4 2
2012 2 0 1
2014 6 1 2
2015 23 1 11
2016 24 7 12
2017 30 6 13
2018 34 2 13
2019 59 7 22
2020 55 0 20
2021 80 5 32
2022 40 2 13
2023 84 3 37
2024 49 1 23
2025 36 3 21

View full timeline →

What Is CEFOPERAZONE\SULBACTAM Used For?

IndicationReports
Pneumonia 153
Anti-infective therapy 106
Infection 87
Antibiotic therapy 52
Product used for unknown indication 40
Lung infection 37
Covid-19 24
Pyrexia 19
Klebsiella infection 17
Sepsis 16

CEFOPERAZONE\SULBACTAM vs Alternatives: Which Is Safer?

CEFOPERAZONE\SULBACTAM vs CEFOTAXIME CEFOPERAZONE\SULBACTAM vs CEFOXITIN CEFOPERAZONE\SULBACTAM vs CEFPODOXIME CEFOPERAZONE\SULBACTAM vs CEFPODOXIME PROXETIL CEFOPERAZONE\SULBACTAM vs CEFPROZIL CEFOPERAZONE\SULBACTAM vs CEFTAROLINE CEFOPERAZONE\SULBACTAM vs CEFTAROLINE FOSAMIL CEFOPERAZONE\SULBACTAM vs CEFTAZIDIME CEFOPERAZONE\SULBACTAM vs CEFTIBUTEN CEFOPERAZONE\SULBACTAM vs CEFTOLOZANE\TAZOBACTAM

Official FDA Label for CEFOPERAZONE\SULBACTAM

Official prescribing information from the FDA-approved drug label.