CETYLPYRIDINIUM: 180 Adverse Event Reports & Safety Profile
Healthy Teeth & Gums — The Probiotic Way
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Active Ingredient: CETYLPYRIDINIUM CHLORIDE · Route: ORAL · Manufacturer: The Procter & Gamble Manufacturing Company · HUMAN OTC DRUG · FDA Label: Available
First Report: 20060101 · Latest Report: 20250707
What Are the Most Common CETYLPYRIDINIUM Side Effects?
All CETYLPYRIDINIUM Side Effects by Frequency
| Side Effect | Reports | % of Total | Deaths | Hosp. |
|---|---|---|---|---|
| Ageusia | 48 | 26.7% | 0 | 2 |
| Oral pain | 24 | 13.3% | 0 | 9 |
| Oral discomfort | 22 | 12.2% | 0 | 2 |
| Dysgeusia | 18 | 10.0% | 0 | 0 |
| Glossodynia | 15 | 8.3% | 0 | 1 |
| Tooth discolouration | 14 | 7.8% | 0 | 2 |
| Hypoaesthesia oral | 13 | 7.2% | 0 | 1 |
| Pain | 13 | 7.2% | 0 | 7 |
| Swelling face | 13 | 7.2% | 0 | 1 |
| Asthenia | 10 | 5.6% | 0 | 8 |
| Fatigue | 10 | 5.6% | 0 | 7 |
| Tongue discomfort | 10 | 5.6% | 0 | 0 |
| Vomiting | 10 | 5.6% | 0 | 8 |
| Wound | 10 | 5.6% | 0 | 7 |
| Abdominal discomfort | 9 | 5.0% | 0 | 8 |
| Blister | 9 | 5.0% | 0 | 7 |
| Burn oral cavity | 9 | 5.0% | 0 | 0 |
| Dizziness | 9 | 5.0% | 0 | 9 |
| Hypoaesthesia | 9 | 5.0% | 0 | 7 |
| Rash | 9 | 5.0% | 0 | 7 |
Who Reports CETYLPYRIDINIUM Side Effects? Age & Gender Data
Gender: 57.0% female, 43.0% male. Average age: 48.1 years. Most reports from: US. View detailed demographics →
Is CETYLPYRIDINIUM Getting Safer? Reports by Year
| Year | Reports | Deaths | Hosp. |
|---|---|---|---|
| 2006 | 2 | 2 | 2 |
| 2010 | 2 | 0 | 2 |
| 2011 | 4 | 0 | 4 |
| 2014 | 19 | 0 | 2 |
| 2015 | 26 | 0 | 0 |
| 2016 | 15 | 0 | 1 |
| 2017 | 22 | 0 | 2 |
| 2018 | 12 | 0 | 1 |
| 2019 | 11 | 0 | 1 |
| 2020 | 6 | 0 | 3 |
| 2021 | 11 | 0 | 0 |
| 2022 | 8 | 0 | 3 |
| 2023 | 8 | 0 | 2 |
| 2024 | 2 | 0 | 0 |
| 2025 | 1 | 0 | 1 |
What Is CETYLPYRIDINIUM Used For?
| Indication | Reports |
|---|---|
| Dental disorder prophylaxis | 43 |
| Gingivitis | 21 |
| Product used for unknown indication | 20 |
| Dental care | 11 |
| Breath odour | 9 |
| Prophylaxis | 6 |
CETYLPYRIDINIUM vs Alternatives: Which Is Safer?
Official FDA Label for CETYLPYRIDINIUM
Official prescribing information from the FDA-approved drug label.
Drug Description
Hello Peace Out Plaque peace out, plaque antigingivitis
Drug facts
FDA Approved Uses (Indications)
Uses Helps prevent gingivitis, an early form of gum disease, and bleeding gums Helps control plaque that leads to gingivitis and bleeding gums
Directions Adults and children 12 years of age and older: Vigorously swish 20 mL (4 teaspoonfuls) of rinse between your teeth twice a day for 30 seconds and then spit out. Do not swallow the rinse.
Children
6 years to under 12 years: Supervise use. Children under 6 years of age: Do not use.
Dosage & Administration
Directions Before opening, turn package over, burst solution packet with thumbs. Peel lid to open.
Remove Mouth
Moisturizer and Applicator Swab.
Attach
Toothbrush to suction line. Clean teeth and oral cavity for approximately one minute. To suction, place thumb over port. To clear tubing, rinse with sterile saline or appropriate solution.
Discard
Toothbrush.
Reattach Covered
Yankauer to suction line.
Place Mouth
Moisturizer on Applicator Swab. Apply as needed to lips and inside mouth. Adults and children 12 years of age and older: use two times daily or as directed by a dentist. Do not swallow the solution. Children ages 6 to 12 years: supervise use. Children under 6 years of age: do not use. Use a bite block when performing oral care on patients with altered levels of consciousness or those who cannot comprehend commands. Ensure foam is intact after use. If not, remove any particles from oral cavity.
Known Adverse Reactions
Adverse reactions DISTRIBUTED BY: Amazon.com Services LLC Seattle, WA 98109 1-877-485-0385 ©2025 Amazon Basics Services LLC or its Affiliates. All rights reserved. www.amazon.com/amazonbasics Made in USA with U.S. and foreign components.
Discard
Seal, Empty & Replace Cap PLASTIC BOTTLE how2recycle.info
Warnings
Warnings Ask a dentist if symptoms persist or condition worsens after regular use. Keep out of reach of children under 6 years of age. If more than used for rinsing is accidentally swallowed, get medical help or contact a Poison Control Center right away. Ask a dentist if symptoms persist or condition worsens after regular use. Keep out of reach of children under 6 years of age. If more than used for rinsing is accidentally swallowed, get medical help or contact a Poison Control Center right away.
Active Ingredient
Drug Facts Active ingredient: Purpose CORINZ ANTISEPTIC CLEANSING AND MOISTURIZING ORAL RINSE: Cetylpyridinium chloride 0.05% Antiseptic Rinse
Inactive Ingredients
Inactive ingredients Water, Propylene Glycol, PEG-40 Hydrogenated Castor Oil, Glycerin, Sodium Saccharin, Sodium Citrate, Herb-Mint Flavor, Menthol, Mentha Piperita Oil, Xylitol, Sucralose, Citric Acid, Melaleuca Alternifolia Leaf Oil, Eugenia Caryophyllus (Clove)
Leaf
Oil, Aloe Barbadensis Leaf Extract, Chamomilla Recutita Flower Extract, Eucalyptus Globulus Leaf Extract, Camellia Sinensis Leaf Extract, Brilliant Blue FCF