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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

CHLORPHENIRAMINE\HYDROCODONE: 1,048 Adverse Event Reports & Safety Profile

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1,048
Total FAERS Reports
207 (19.8%)
Deaths Reported
33
Hospitalizations
1,048
As Primary/Secondary Suspect
4
Disabilities

Active Ingredient: CHLORPHENIRAMINE MALEATE\HYDROCODONE BITARTRATE ·

First Report: 19980320 · Latest Report: 20250101

What Are the Most Common CHLORPHENIRAMINE\HYDROCODONE Side Effects?

#1 Most Reported
Dependence
829 reports (79.1%)
#2 Most Reported
Overdose
467 reports (44.6%)
#3 Most Reported
Death
189 reports (18.0%)

All CHLORPHENIRAMINE\HYDROCODONE Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Dependence 829 79.1% 155 3
Overdose 467 44.6% 137 2
Death 189 18.0% 189 2
Depression 49 4.7% 6 0
Ill-defined disorder 41 3.9% 8 1
Withdrawal syndrome 36 3.4% 4 2
Anxiety 35 3.3% 4 0
Suicide attempt 19 1.8% 4 3
Drug ineffective 18 1.7% 0 0
Product prescribing issue 15 1.4% 6 0
Somnolence 13 1.2% 2 4
Constipation 12 1.2% 3 2
Drug hypersensitivity 12 1.2% 0 0
Nausea 12 1.2% 2 3
Pain 12 1.2% 3 1
Drug dependence 11 1.1% 3 2
Amnesia 10 1.0% 0 0
Confusional state 10 1.0% 1 2
Insomnia 10 1.0% 1 0
Disability 9 0.9% 1 0

Who Reports CHLORPHENIRAMINE\HYDROCODONE Side Effects? Age & Gender Data

Gender: 43.2% female, 56.8% male. Average age: 51.1 years. Most reports from: US. View detailed demographics →

Is CHLORPHENIRAMINE\HYDROCODONE Getting Safer? Reports by Year

YearReportsDeathsHosp.
2003 1 0 0
2005 1 1 0
2006 2 0 0
2007 1 0 0
2008 1 0 0
2009 1 0 1
2010 1 0 0
2011 1 0 0
2012 1 1 0
2013 1 1 0
2014 4 0 0
2015 9 0 3
2016 8 2 1
2017 4 1 1
2018 4 1 1
2019 4 0 0
2020 4 0 1
2021 2 0 0
2022 2 0 0
2023 2 0 0
2025 1 0 0

View full timeline →

What Is CHLORPHENIRAMINE\HYDROCODONE Used For?

IndicationReports
Product used for unknown indication 96
Cough 50
Pain 11
Back pain 5

CHLORPHENIRAMINE\HYDROCODONE vs Alternatives: Which Is Safer?

CHLORPHENIRAMINE\HYDROCODONE vs CHLORPHENIRAMINE\HYDROCODONE\PSEUDOEPHEDRINE CHLORPHENIRAMINE\HYDROCODONE vs CHLORPHENIRAMINE\IBUPROFEN\PHENYLEPHRINE CHLORPHENIRAMINE\HYDROCODONE vs CHLORPHENIRAMINE\IBUPROFEN\PSEUDOEPHEDRINE CHLORPHENIRAMINE\HYDROCODONE vs CHLORPROMAZINE CHLORPHENIRAMINE\HYDROCODONE vs CHLORPROTHIXENE CHLORPHENIRAMINE\HYDROCODONE vs CHLORTHALIDONE CHLORPHENIRAMINE\HYDROCODONE vs CHLORZOXAZONE CHLORPHENIRAMINE\HYDROCODONE vs CHOLECALCIFEROL CHLORPHENIRAMINE\HYDROCODONE vs CHOLECALCIFEROL\ERGOCALCIFEROL CHLORPHENIRAMINE\HYDROCODONE vs CHOLESTYRAMINE

Official FDA Label for CHLORPHENIRAMINE\HYDROCODONE

Official prescribing information from the FDA-approved drug label.