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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

CILASTATIN\IMIPENEM: 4,873 Adverse Event Reports & Safety Profile

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4,873
Total FAERS Reports
643 (13.2%)
Deaths Reported
1,798
Hospitalizations
4,873
As Primary/Secondary Suspect
456
Life-Threatening
111
Disabilities

Active Ingredient: CILASTATIN SODIUM\IMIPENEM ·

First Report: 19911104 · Latest Report: 20250923

What Are the Most Common CILASTATIN\IMIPENEM Side Effects?

#1 Most Reported
Epilepsy
615 reports (12.6%)
#2 Most Reported
Product use in unapproved indication
385 reports (7.9%)
#3 Most Reported
Drug ineffective
321 reports (6.6%)

All CILASTATIN\IMIPENEM Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Epilepsy 615 12.6% 3 128
Product use in unapproved indication 385 7.9% 25 53
Drug ineffective 321 6.6% 133 122
Delirium 309 6.3% 1 53
Off label use 248 5.1% 58 81
Pyrexia 168 3.5% 47 104
Seizure 155 3.2% 15 59
Nausea 145 3.0% 12 52
Vomiting 133 2.7% 16 48
Diarrhoea 122 2.5% 27 64
Drug reaction with eosinophilia and systemic symptoms 122 2.5% 12 90
Pathogen resistance 122 2.5% 39 54
Dyspnoea 115 2.4% 32 60
Condition aggravated 103 2.1% 31 62
Pneumonia 98 2.0% 37 59
Confusional state 96 2.0% 6 65
Thrombocytopenia 96 2.0% 19 58
Mental disorder 95 2.0% 0 29
Septic shock 94 1.9% 62 48
Muscle twitching 93 1.9% 0 25

Who Reports CILASTATIN\IMIPENEM Side Effects? Age & Gender Data

Gender: 41.1% female, 58.9% male. Average age: 58.4 years. Most reports from: CN. View detailed demographics →

Is CILASTATIN\IMIPENEM Getting Safer? Reports by Year

YearReportsDeathsHosp.
2000 2 0 2
2001 1 0 1
2002 2 1 2
2003 1 0 1
2004 4 4 1
2005 2 1 2
2006 4 1 3
2007 2 0 1
2008 9 0 8
2009 18 4 15
2010 18 6 15
2011 11 2 4
2012 29 1 19
2013 42 9 34
2014 104 9 65
2015 166 15 87
2016 202 22 108
2017 273 32 132
2018 379 119 140
2019 337 46 149
2020 266 32 96
2021 363 28 132
2022 496 20 139
2023 536 7 173
2024 242 1 85
2025 124 4 41

View full timeline →

What Is CILASTATIN\IMIPENEM Used For?

IndicationReports
Pneumonia 587
Anti-infective therapy 556
Infection 537
Product used for unknown indication 277
Mycobacterium abscessus infection 197
Sepsis 185
Tuberculosis 177
Antibiotic therapy 170
Nocardiosis 116
Lung infection 104

CILASTATIN\IMIPENEM vs Alternatives: Which Is Safer?

CILASTATIN\IMIPENEM vs CILAZAPRIL ANHYDROUS CILASTATIN\IMIPENEM vs CILGAVIMAB\TIXAGEVIMAB CILASTATIN\IMIPENEM vs CILOSTAZOL CILASTATIN\IMIPENEM vs CILTACABTAGENE AUTOLEUCEL CILASTATIN\IMIPENEM vs CIMETIDINE CILASTATIN\IMIPENEM vs CIMZIA CILASTATIN\IMIPENEM vs CINACALCET CILASTATIN\IMIPENEM vs CINNARIZINE CILASTATIN\IMIPENEM vs CINRYZE CILASTATIN\IMIPENEM vs CIPRO

Official FDA Label for CILASTATIN\IMIPENEM

Official prescribing information from the FDA-approved drug label.