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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

CLOXACILLIN: 994 Adverse Event Reports & Safety Profile

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994
Total FAERS Reports
106 (10.7%)
Deaths Reported
618
Hospitalizations
994
As Primary/Secondary Suspect
90
Life-Threatening
8
Disabilities
Approved Prior to Jan 1, 1982
FDA Approved
Discontinued
Status
Yes
Generic Available

FDA Application: 050192 ·

First Report: 19841026 · Latest Report: 20250822

What Are the Most Common CLOXACILLIN Side Effects?

#1 Most Reported
Acute kidney injury
180 reports (18.1%)
#2 Most Reported
Drug reaction with eosinophilia and systemic symptoms
121 reports (12.2%)
#3 Most Reported
Drug ineffective
65 reports (6.5%)

All CLOXACILLIN Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Acute kidney injury 180 18.1% 29 124
Drug reaction with eosinophilia and systemic symptoms 121 12.2% 2 89
Drug ineffective 65 6.5% 18 32
Thrombocytopenia 63 6.3% 3 44
Agranulocytosis 53 5.3% 0 41
Rash maculo-papular 51 5.1% 0 28
Rash 49 4.9% 9 25
Pyrexia 47 4.7% 0 38
Eosinophilia 41 4.1% 1 26
Condition aggravated 39 3.9% 0 27
Neutropenia 38 3.8% 1 27
Tubulointerstitial nephritis 38 3.8% 0 37
Drug hypersensitivity 35 3.5% 0 7
Cholestasis 34 3.4% 3 25
Off label use 33 3.3% 3 11
Toxic epidermal necrolysis 33 3.3% 1 29
Jaundice 27 2.7% 2 21
Leukopenia 26 2.6% 0 21
Pancytopenia 24 2.4% 5 18
Product use in unapproved indication 24 2.4% 0 11

Who Reports CLOXACILLIN Side Effects? Age & Gender Data

Gender: 37.9% female, 62.1% male. Average age: 60.0 years. Most reports from: FR. View detailed demographics →

Is CLOXACILLIN Getting Safer? Reports by Year

YearReportsDeathsHosp.
2005 1 0 1
2010 3 0 3
2011 2 0 0
2012 10 3 9
2013 10 1 6
2014 33 3 22
2015 37 2 27
2016 46 8 40
2017 48 11 34
2018 85 13 48
2019 105 5 77
2020 100 19 69
2021 59 0 39
2022 91 11 56
2023 37 1 22
2024 22 1 3
2025 13 0 12

View full timeline →

What Is CLOXACILLIN Used For?

IndicationReports
Product used for unknown indication 149
Infection 105
Staphylococcal infection 85
Endocarditis 68
Staphylococcal bacteraemia 51
Arthritis bacterial 33
Sepsis 33
Bacteraemia 31
Device related infection 28
Antibiotic therapy 25

CLOXACILLIN vs Alternatives: Which Is Safer?

CLOXACILLIN vs CLOXAZOLAM CLOXACILLIN vs CLOZAPINE CLOXACILLIN vs CLOZARIL CLOXACILLIN vs COAGULATION FACTOR IX HUMAN\COAGULATION FACTOR VII HUMAN\COAGULATION FACTOR X HUMAN\PROTEIN C\PROTEIN S HUMAN\PROTHROMBIN CLOXACILLIN vs COAGULATION FACTOR IX HUMAN\COAGULATION FACTOR VII HUMAN\COAGULATION FACTOR X HUMAN\PROTHROMBIN CLOXACILLIN vs COAGULATION FACTOR IX RECOMBINANT HUMAN CLOXACILLIN vs COAGULATION FACTOR IX RECOMBINANT HUMAN\ISOPROPYL ALCOHOL CLOXACILLIN vs COAGULATION FACTOR VIIA RECOMBINANT HUMAN CLOXACILLIN vs COBAMAMIDE CLOXACILLIN vs COBICISTAT

Official FDA Label for CLOXACILLIN

Official prescribing information from the FDA-approved drug label.