COBIMETINIB for Neoplasm: Side Effects & Safety Data
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There are 68 adverse event reports in the FDA FAERS database where COBIMETINIB was used for Neoplasm.
Most Reported Side Effects for COBIMETINIB
| Side Effect | Reports | % | Deaths | Hosp. |
|---|---|---|---|---|
| Diarrhoea | 412 | 10.1% | 39 | 214 |
| Off label use | 411 | 10.1% | 40 | 65 |
| Rash | 369 | 9.1% | 11 | 166 |
| Pyrexia | 332 | 8.2% | 19 | 228 |
| Death | 231 | 5.7% | 230 | 23 |
| Nausea | 206 | 5.1% | 17 | 105 |
| Fatigue | 198 | 4.9% | 15 | 93 |
| No adverse event | 178 | 4.4% | 0 | 1 |
| Vomiting | 168 | 4.1% | 20 | 108 |
| Acute kidney injury | 133 | 3.3% | 18 | 114 |
| Photosensitivity reaction | 124 | 3.1% | 10 | 44 |
| Asthenia | 119 | 2.9% | 13 | 68 |
| Rash maculo-papular | 118 | 2.9% | 7 | 73 |
| Blood creatine phosphokinase increased | 114 | 2.8% | 5 | 58 |
| Drug reaction with eosinophilia and systemic symptoms | 113 | 2.8% | 6 | 72 |
Other Indications for COBIMETINIB
Malignant melanoma (1,324)
Metastatic malignant melanoma (898)
Product used for unknown indication (402)
Histiocytosis (98)
Erdheim-chester disease (90)
Plasma cell myeloma (76)
Neoplasm malignant (70)
Langerhans' cell histiocytosis (56)
Cholangiocarcinoma (53)
Malignant melanoma stage iv (53)
Other Drugs Used for Neoplasm
BEVACIZUMAB (502)
ATEZOLIZUMAB (404)
CYCLOPHOSPHAMIDE (385)
CARBOPLATIN (283)
PACLITAXEL (267)
NIVOLUMAB (219)
OXALIPLATIN (185)
PEMBROLIZUMAB (173)
LENALIDOMIDE (171)
DOXORUBICIN (150)