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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

EPINEPHRINE\LIDOCAINE: 2,422 Adverse Event Reports & Safety Profile

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2,422
Total FAERS Reports
36 (1.5%)
Deaths Reported
311
Hospitalizations
2,422
As Primary/Secondary Suspect
188
Life-Threatening
37
Disabilities

Active Ingredient: EPINEPHRINE BITARTRATE\LIDOCAINE HYDROCHLORIDE ·

First Report: 19570101 · Latest Report: 20250925

What Are the Most Common EPINEPHRINE\LIDOCAINE Side Effects?

#1 Most Reported
Drug ineffective
1,040 reports (42.9%)
#2 Most Reported
Therapeutic product effect decreased
73 reports (3.0%)
#3 Most Reported
Off label use
73 reports (3.0%)

All EPINEPHRINE\LIDOCAINE Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Drug ineffective 1,040 42.9% 0 4
Haemorrhage 73 3.0% 0 0
Off label use 73 3.0% 1 12
Therapeutic product effect decreased 73 3.0% 0 0
Pain 65 2.7% 0 2
Anaphylactic shock 61 2.5% 11 19
Hypotension 61 2.5% 2 29
Bradycardia 60 2.5% 0 30
Injection site pain 59 2.4% 0 1
Dizziness 57 2.4% 0 8
Dyspnoea 56 2.3% 0 16
Tremor 43 1.8% 0 9
Loss of consciousness 40 1.7% 3 15
Rash 38 1.6% 0 14
Hypoaesthesia 37 1.5% 0 8
Tachycardia 36 1.5% 0 14
Cardiac arrest 35 1.5% 2 23
Palpitations 35 1.5% 1 2
Seizure 35 1.5% 0 15
Discomfort 33 1.4% 0 0

Who Reports EPINEPHRINE\LIDOCAINE Side Effects? Age & Gender Data

Gender: 62.7% female, 37.3% male. Average age: 46.0 years. Most reports from: US. View detailed demographics →

Is EPINEPHRINE\LIDOCAINE Getting Safer? Reports by Year

YearReportsDeathsHosp.
2001 1 0 0
2002 2 0 1
2003 1 0 0
2006 1 0 0
2008 2 0 1
2009 4 0 1
2010 2 0 2
2011 6 0 0
2012 10 0 6
2013 12 2 1
2014 35 1 6
2015 119 0 1
2016 152 0 9
2017 107 5 24
2018 149 0 25
2019 201 0 24
2020 59 3 16
2021 94 1 13
2022 99 10 14
2023 131 7 20
2024 87 0 16
2025 18 0 4

View full timeline →

What Is EPINEPHRINE\LIDOCAINE Used For?

IndicationReports
Local anaesthesia 856
Dental local anaesthesia 500
Product used for unknown indication 205
Anaesthesia 122
Epidural anaesthesia 54
Nerve block 38
Analgesic therapy 29
Anaesthesia procedure 28
Infiltration anaesthesia 22
Pain management 22

EPINEPHRINE\LIDOCAINE vs Alternatives: Which Is Safer?

EPINEPHRINE\LIDOCAINE vs EPIPEN EPINEPHRINE\LIDOCAINE vs EPIRUBICIN EPINEPHRINE\LIDOCAINE vs EPLERENONE EPINEPHRINE\LIDOCAINE vs EPLONTERSEN EPINEPHRINE\LIDOCAINE vs EPOETIN ALFA-EPBX EPINEPHRINE\LIDOCAINE vs EPOGEN EPINEPHRINE\LIDOCAINE vs EPOPROSTENOL EPINEPHRINE\LIDOCAINE vs EPTIFIBATIDE EPINEPHRINE\LIDOCAINE vs EPTINEZUMAB-JJMR EPINEPHRINE\LIDOCAINE vs EPTINEZUMAB\EPTINEZUMAB-JJMR

Official FDA Label for EPINEPHRINE\LIDOCAINE

Official prescribing information from the FDA-approved drug label.