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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

ESTRADIOL\LEVONORGESTREL: 1,255 Adverse Event Reports & Safety Profile

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Thyrafemme Balance — 14 gentle ingredients for energy, mood & hormonal harmony.

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1,255
Total FAERS Reports
0
Deaths Reported
6
Hospitalizations
1,255
As Primary/Secondary Suspect
1
Life-Threatening
3
Disabilities

First Report: 19970901 · Latest Report: 20250805

What Are the Most Common ESTRADIOL\LEVONORGESTREL Side Effects?

#1 Most Reported
Product adhesion issue
554 reports (44.1%)
#2 Most Reported
Product physical issue
305 reports (24.3%)
#3 Most Reported
Wrong technique in product usage process
246 reports (19.6%)

All ESTRADIOL\LEVONORGESTREL Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Product adhesion issue 554 44.1% 0 0
Product physical issue 305 24.3% 0 0
Wrong technique in product usage process 246 19.6% 0 0
Device adhesion issue 195 15.5% 0 0
Hot flush 127 10.1% 0 0
Drug ineffective 126 10.0% 0 0
Application site rash 90 7.2% 0 0
Device breakage 87 6.9% 0 0
Drug dose omission 81 6.5% 0 0
Product quality issue 81 6.5% 0 0
Application site pruritus 63 5.0% 0 0
Wrong technique in device usage process 60 4.8% 0 0
Product use issue 58 4.6% 0 0
Application site irritation 52 4.1% 0 0
Uterine haemorrhage 50 4.0% 0 0
Application site erythema 45 3.6% 0 0
Postmenopausal haemorrhage 45 3.6% 0 0
Feeling abnormal 32 2.6% 0 0
Headache 31 2.5% 0 0
Incorrect dose administered 28 2.2% 0 0

Who Reports ESTRADIOL\LEVONORGESTREL Side Effects? Age & Gender Data

Gender: 100.0% female, 0.0% male. Average age: 55.3 years. Most reports from: US. View detailed demographics →

Is ESTRADIOL\LEVONORGESTREL Getting Safer? Reports by Year

YearReportsDeathsHosp.
2002 1 0 0
2003 2 0 0
2004 1 0 0
2007 1 0 0
2008 1 0 0
2010 1 0 0
2011 1 0 0
2012 3 0 0
2013 6 0 1
2014 19 0 0
2015 43 0 0
2016 45 0 1
2017 107 0 1
2018 105 0 2
2019 59 0 0
2020 61 0 0
2021 36 0 0
2022 33 0 0
2023 35 0 1
2024 42 0 0
2025 39 0 0

View full timeline →

What Is ESTRADIOL\LEVONORGESTREL Used For?

IndicationReports
Hormone replacement therapy 258
Menopause 149
Menopausal symptoms 131
Hot flush 119
Menopausal disorder 21
Hormone therapy 18
Night sweats 10
Product used for unknown indication 9
Insomnia 8
Mood swings 6

ESTRADIOL\LEVONORGESTREL vs Alternatives: Which Is Safer?

ESTRADIOL\LEVONORGESTREL vs ESTRADIOL\NORETHINDRONE ESTRADIOL\LEVONORGESTREL vs ESTRADIOL\NORETHINDRONE\RELUGOLIX ESTRADIOL\LEVONORGESTREL vs ESTRADIOL\PROGESTERONE ESTRADIOL\LEVONORGESTREL vs ESTRAMUSTINE ESTRADIOL\LEVONORGESTREL vs ESTRING ESTRADIOL\LEVONORGESTREL vs ESTRIOL ESTRADIOL\LEVONORGESTREL vs ESTROGENS ESTRADIOL\LEVONORGESTREL vs ESTROGENS, CONJUGATED ESTRADIOL\LEVONORGESTREL vs ESTROGENS, CONJUGATED\MEDROXYPROGESTERONE ESTRADIOL\LEVONORGESTREL vs ESTROGENS, ESTERIFIED

Official FDA Label for ESTRADIOL\LEVONORGESTREL

Official prescribing information from the FDA-approved drug label.