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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

ETHINYL ESTRADIOL\ETONOGESTREL: 11,613 Adverse Event Reports & Safety Profile

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11,613
Total FAERS Reports
130 (1.1%)
Deaths Reported
3,386
Hospitalizations
11,613
As Primary/Secondary Suspect
311
Life-Threatening
576
Disabilities

First Report: 1997 · Latest Report: 20250904

What Are the Most Common ETHINYL ESTRADIOL\ETONOGESTREL Side Effects?

#1 Most Reported
Pulmonary embolism
2,370 reports (20.4%)
#2 Most Reported
Deep vein thrombosis
1,577 reports (13.6%)
#3 Most Reported
Inappropriate schedule of drug administration
1,464 reports (12.6%)

All ETHINYL ESTRADIOL\ETONOGESTREL Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Pulmonary embolism 2,370 20.4% 97 2,125
Deep vein thrombosis 1,577 13.6% 39 1,220
Inappropriate schedule of drug administration 1,464 12.6% 2 52
No adverse event 1,280 11.0% 0 0
Device expulsion 986 8.5% 1 27
Device breakage 741 6.4% 0 4
Incorrect drug administration duration 740 6.4% 2 58
Unintended pregnancy 543 4.7% 2 87
Headache 530 4.6% 4 288
Depression 511 4.4% 5 343
Anxiety 483 4.2% 5 330
Migraine 480 4.1% 5 309
Off label use 457 3.9% 10 374
Product quality issue 445 3.8% 0 5
Metrorrhagia 431 3.7% 0 57
Nausea 411 3.5% 1 181
Vaginal haemorrhage 403 3.5% 1 64
Menorrhagia 353 3.0% 0 138
Pregnancy with contraceptive device 334 2.9% 0 27
Chest pain 284 2.5% 1 245

Who Reports ETHINYL ESTRADIOL\ETONOGESTREL Side Effects? Age & Gender Data

Gender: 99.5% female, 0.5% male. Average age: 29.3 years. Most reports from: US. View detailed demographics →

Is ETHINYL ESTRADIOL\ETONOGESTREL Getting Safer? Reports by Year

YearReportsDeathsHosp.
2000 3 0 3
2001 8 0 6
2002 15 0 12
2003 62 0 47
2004 79 0 64
2005 131 1 111
2006 258 10 222
2007 303 12 260
2008 314 10 262
2009 372 5 292
2010 407 11 327
2011 491 10 364
2012 604 12 458
2013 409 10 269
2014 571 2 113
2015 793 11 97
2016 675 5 101
2017 620 4 76
2018 444 1 45
2019 376 3 35
2020 432 2 22
2021 280 2 17
2022 178 0 7
2023 104 1 11
2024 80 0 12
2025 28 1 10

View full timeline →

What Is ETHINYL ESTRADIOL\ETONOGESTREL Used For?

IndicationReports
Contraception 5,815
Product used for unknown indication 974
Menstrual cycle management 275
Menstruation irregular 163
Menorrhagia 152
Dysmenorrhoea 112
Endometriosis 80
Polycystic ovaries 61
Menstrual disorder 49
Ovarian cyst 47

ETHINYL ESTRADIOL\ETONOGESTREL vs Alternatives: Which Is Safer?

ETHINYL ESTRADIOL\ETONOGESTREL vs ETHINYL ESTRADIOL\FERROUS\NORETHINDRONE ETHINYL ESTRADIOL\ETONOGESTREL vs ETHINYL ESTRADIOL\GESTODENE ETHINYL ESTRADIOL\ETONOGESTREL vs ETHINYL ESTRADIOL\LEVONORGESTREL ETHINYL ESTRADIOL\ETONOGESTREL vs ETHINYL ESTRADIOL\NORELGESTROMIN ETHINYL ESTRADIOL\ETONOGESTREL vs ETHINYL ESTRADIOL\NORETHINDRONE ETHINYL ESTRADIOL\ETONOGESTREL vs ETHINYL ESTRADIOL\NORGESTIMATE ETHINYL ESTRADIOL\ETONOGESTREL vs ETHINYL ESTRADIOL\NORGESTREL ETHINYL ESTRADIOL\ETONOGESTREL vs ETHINYL ESTRADIOL\SEGESTERONE ETHINYL ESTRADIOL\ETONOGESTREL vs ETHIODIZED OIL ETHINYL ESTRADIOL\ETONOGESTREL vs ETHIONAMIDE

Official FDA Label for ETHINYL ESTRADIOL\ETONOGESTREL

Official prescribing information from the FDA-approved drug label.