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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

ETHINYL ESTRADIOL\LEVONORGESTREL: 4,614 Adverse Event Reports & Safety Profile

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4,614
Total FAERS Reports
104 (2.3%)
Deaths Reported
1,046
Hospitalizations
4,614
As Primary/Secondary Suspect
280
Life-Threatening
154
Disabilities

First Report: 1987 · Latest Report: 20250908

What Are the Most Common ETHINYL ESTRADIOL\LEVONORGESTREL Side Effects?

#1 Most Reported
Product adhesion issue
522 reports (11.3%)
#2 Most Reported
Pulmonary embolism
324 reports (7.0%)
#3 Most Reported
Drug ineffective
269 reports (5.8%)

All ETHINYL ESTRADIOL\LEVONORGESTREL Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Product adhesion issue 522 11.3% 0 0
Pulmonary embolism 324 7.0% 36 229
Drug ineffective 269 5.8% 3 21
Headache 241 5.2% 1 92
Deep vein thrombosis 203 4.4% 4 122
Nausea 201 4.4% 0 50
Off label use 189 4.1% 6 57
Anxiety 178 3.9% 0 13
Pain 168 3.6% 6 26
Pregnancy on oral contraceptive 166 3.6% 0 5
Metrorrhagia 153 3.3% 0 7
Vaginal haemorrhage 146 3.2% 0 15
Fatigue 125 2.7% 2 44
Intermenstrual bleeding 124 2.7% 0 4
Emotional distress 122 2.6% 0 5
Product use in unapproved indication 121 2.6% 4 18
Vomiting 118 2.6% 3 56
Dizziness 116 2.5% 32 25
Partner stress 113 2.5% 0 0
Menstrual disorder 112 2.4% 0 2

Who Reports ETHINYL ESTRADIOL\LEVONORGESTREL Side Effects? Age & Gender Data

Gender: 99.3% female, 0.7% male. Average age: 30.0 years. Most reports from: US. View detailed demographics →

Is ETHINYL ESTRADIOL\LEVONORGESTREL Getting Safer? Reports by Year

YearReportsDeathsHosp.
2000 4 0 0
2001 2 0 1
2002 2 0 1
2003 5 0 2
2004 4 0 3
2005 1 0 0
2006 2 0 1
2007 12 2 6
2008 7 0 2
2009 9 1 5
2010 19 0 12
2011 22 1 7
2012 23 1 17
2013 56 0 18
2014 174 2 78
2015 162 1 61
2016 207 2 64
2017 179 2 51
2018 314 11 143
2019 246 6 72
2020 186 4 47
2021 261 6 84
2022 294 1 32
2023 212 1 26
2024 129 0 25
2025 58 0 23

View full timeline →

What Is ETHINYL ESTRADIOL\LEVONORGESTREL Used For?

IndicationReports
Contraception 1,968
Product used for unknown indication 1,064
Oral contraception 454
Menstrual cycle management 131
Dysmenorrhoea 100
Menstruation irregular 62
Hormonal contraception 58
Endometriosis 56
Heavy menstrual bleeding 44
Menorrhagia 44

ETHINYL ESTRADIOL\LEVONORGESTREL vs Alternatives: Which Is Safer?

ETHINYL ESTRADIOL\LEVONORGESTREL vs ETHINYL ESTRADIOL\NORELGESTROMIN ETHINYL ESTRADIOL\LEVONORGESTREL vs ETHINYL ESTRADIOL\NORETHINDRONE ETHINYL ESTRADIOL\LEVONORGESTREL vs ETHINYL ESTRADIOL\NORGESTIMATE ETHINYL ESTRADIOL\LEVONORGESTREL vs ETHINYL ESTRADIOL\NORGESTREL ETHINYL ESTRADIOL\LEVONORGESTREL vs ETHINYL ESTRADIOL\SEGESTERONE ETHINYL ESTRADIOL\LEVONORGESTREL vs ETHIODIZED OIL ETHINYL ESTRADIOL\LEVONORGESTREL vs ETHIONAMIDE ETHINYL ESTRADIOL\LEVONORGESTREL vs ETHOSUXIMIDE ETHINYL ESTRADIOL\LEVONORGESTREL vs ETHYL ICOSAPENTATE ETHINYL ESTRADIOL\LEVONORGESTREL vs ETHYL LOFLAZEPATE

Official FDA Label for ETHINYL ESTRADIOL\LEVONORGESTREL

Official prescribing information from the FDA-approved drug label.