HISTAMINE Drug Interactions: What You Need to Know
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Drug Interactions (FDA Label)
Drug Interactions Drugs can interfere with the performance of skin tests in general, and specifically with histamine 1 . Antihistamines: Response to histamine is suppressed by antihistamines. The length of suppression varies, and is dependent on individual patient, type of antihistamine and length of time the patient has been on antihistamines. The duration of this suppression may be as little as 24 hours (chlorpheniramine), and can be as long as 40 days (astemizole).
Tricyclic
Antidepressants: These exert a potent and sustained decrease of skin reactivity to histamine, which may last for a few weeks.
Beta
2 Agonists: Oral terbutaline and parenteral ephedrine, in general, have been shown to decrease allergen induced wheal. Theoretically, this may also reduce whealing capacity to histamine. Dopamine: Intravenous infusion of dopamine has been shown to inhibit skin test responses to histamine.
Beta Blocking
Agents: Propranolol can significantly increase skin test reactivity, including histamine.
Other
Drugs: Short acting steroids, inhaled beta agonists, theophylline and cromolyn do not seem to affect skin test response.
Contraindications
CONTRAINDICATIONS Histamine should not be injected into individuals with hypotension, severe hypertension, severe cardiac, pulmonary, or renal disease. Not to be used for diagnosis of pheochromocytoma or to test the ability of the gastric mucosa to secrete hydrochloric acid.
Related Warnings
Warnings For external use only Do not use
- on wounds or damaged skin
- if you are allergic to ingredients in this product When using this product
- avoid contact with the eyes. If product gets into the eyes, rinse thoroughly with water
- do not bandage tightly or use a heating pad Stop use and ask a doctor if
- rash appears
- condition worsens, or if symptoms persist for more than 7 days, or if symptoms clear up and occur again within a few days If pregnant or breastfeeding, ask a health professional before use. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.