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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

HYALURONATE: 568 Adverse Event Reports & Safety Profile

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568
Total FAERS Reports
34 (6.0%)
Deaths Reported
242
Hospitalizations
568
As Primary/Secondary Suspect
30
Life-Threatening
22
Disabilities

Active Ingredient: HYALURONATE SODIUM ·

First Report: 2005 · Latest Report: 20250825

What Are the Most Common HYALURONATE Side Effects?

#1 Most Reported
Headache
129 reports (22.7%)
#2 Most Reported
Hypertension
124 reports (21.8%)
#3 Most Reported
Hypothyroidism
114 reports (20.1%)

All HYALURONATE Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Headache 129 22.7% 11 116
Hypertension 124 21.8% 12 114
Hypothyroidism 114 20.1% 0 109
Gastrooesophageal reflux disease 112 19.7% 1 106
Therapeutic product effect incomplete 111 19.5% 2 103
Asthma 110 19.4% 4 105
Fibromyalgia 110 19.4% 4 105
Cardiac disorder 108 19.0% 0 102
Burning sensation 107 18.8% 0 101
Blood test abnormal 106 18.7% 0 100
Sensitisation 106 18.7% 0 101
Sleep disorder due to a general medical condition 106 18.7% 3 101
Carpal tunnel syndrome 105 18.5% 0 100
Rhinitis allergic 105 18.5% 0 100
Polycystic ovaries 104 18.3% 0 99
Sleep apnoea syndrome 104 18.3% 0 99
Dyspnoea 93 16.4% 11 91
Loss of personal independence in daily activities 93 16.4% 2 89
Renal disorder 93 16.4% 0 88
Ejection fraction 81 14.3% 0 76

Who Reports HYALURONATE Side Effects? Age & Gender Data

Gender: 73.1% female, 26.9% male. Average age: 58.3 years. Most reports from: CA. View detailed demographics →

Is HYALURONATE Getting Safer? Reports by Year

YearReportsDeathsHosp.
2005 1 0 1
2006 1 0 0
2007 12 0 0
2008 2 0 1
2010 5 0 3
2011 1 0 0
2013 3 0 0
2014 11 0 3
2015 54 11 31
2016 19 1 2
2017 35 5 22
2018 15 0 8
2019 19 0 0
2020 23 2 4
2021 25 1 12
2022 18 0 3
2023 14 0 4
2024 8 0 3
2025 6 0 0

View full timeline →

What Is HYALURONATE Used For?

IndicationReports
Product used for unknown indication 255
Osteoarthritis 71
Dry eye 36
Cataract operation 16
Arthralgia 12
Breast cancer metastatic 12
Preoperative care 10
Postoperative care 8
Arthropathy 5

HYALURONATE vs Alternatives: Which Is Safer?

HYALURONATE vs HYALURONIC ACID HYALURONATE vs HYALURONIC ACID\LIDOCAINE HYALURONATE vs HYALURONIDASE HYALURONATE vs HYALURONIDASE-OCSQ\OCRELIZUMAB HYALURONATE vs HYALURONIDASE \RITUXIMAB HYALURONATE vs HYALURONIDASE-ZZXF\PERTUZUMAB\TRASTUZUMAB HYALURONATE vs HYDRALAZINE HYALURONATE vs HYDRALAZINE\ISOSORBIDE DINITRATE HYALURONATE vs HYDROCHLOROTHIAZIDE HYALURONATE vs HYDROCHLOROTHIAZIDE\IRBESARTAN

Official FDA Label for HYALURONATE

Official prescribing information from the FDA-approved drug label.