HYALURONIC ACID: 630 Adverse Event Reports & Safety Profile
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Route: CUTANEOUS · Manufacturer: Shengnan (Guangzhou) Cosmetics Co., LTD · HUMAN OTC DRUG · FDA Label: Available
First Report: 20060714 · Latest Report: 20250723
What Are the Most Common HYALURONIC ACID Side Effects?
All HYALURONIC ACID Side Effects by Frequency
| Side Effect | Reports | % of Total | Deaths | Hosp. |
|---|---|---|---|---|
| Off label use | 184 | 29.2% | 0 | 11 |
| Drug ineffective | 75 | 11.9% | 1 | 7 |
| Swelling face | 65 | 10.3% | 0 | 11 |
| Erythema | 50 | 7.9% | 0 | 4 |
| Headache | 46 | 7.3% | 1 | 9 |
| Pain | 44 | 7.0% | 0 | 5 |
| Swelling | 39 | 6.2% | 0 | 2 |
| Product preparation error | 38 | 6.0% | 0 | 1 |
| Injection site pain | 35 | 5.6% | 0 | 3 |
| Contusion | 34 | 5.4% | 0 | 2 |
| Eyelid ptosis | 30 | 4.8% | 0 | 1 |
| Injection site swelling | 30 | 4.8% | 0 | 3 |
| Lip swelling | 30 | 4.8% | 0 | 3 |
| Rash | 27 | 4.3% | 0 | 3 |
| Vision blurred | 27 | 4.3% | 0 | 3 |
| Dizziness | 26 | 4.1% | 1 | 10 |
| Dyspnoea | 26 | 4.1% | 0 | 10 |
| Hypoaesthesia | 26 | 4.1% | 0 | 4 |
| Eye swelling | 25 | 4.0% | 0 | 3 |
| Injection site mass | 25 | 4.0% | 0 | 1 |
Who Reports HYALURONIC ACID Side Effects? Age & Gender Data
Gender: 95.1% female, 4.9% male. Average age: 51.7 years. Most reports from: US. View detailed demographics →
Is HYALURONIC ACID Getting Safer? Reports by Year
| Year | Reports | Deaths | Hosp. |
|---|---|---|---|
| 2006 | 1 | 0 | 0 |
| 2008 | 1 | 0 | 0 |
| 2010 | 1 | 0 | 0 |
| 2011 | 6 | 0 | 1 |
| 2012 | 2 | 0 | 0 |
| 2013 | 6 | 0 | 0 |
| 2014 | 38 | 0 | 3 |
| 2015 | 34 | 1 | 7 |
| 2016 | 34 | 1 | 3 |
| 2017 | 31 | 1 | 4 |
| 2018 | 52 | 0 | 2 |
| 2019 | 52 | 1 | 7 |
| 2020 | 24 | 0 | 1 |
| 2021 | 34 | 0 | 5 |
| 2022 | 38 | 4 | 4 |
| 2023 | 27 | 1 | 7 |
| 2024 | 10 | 0 | 0 |
| 2025 | 7 | 0 | 1 |
What Is HYALURONIC ACID Used For?
| Indication | Reports |
|---|---|
| Product used for unknown indication | 229 |
| Skin wrinkling | 162 |
| Skin cosmetic procedure | 93 |
| Dermal filler injection | 29 |
| Lip cosmetic procedure | 17 |
| Osteoarthritis | 6 |
HYALURONIC ACID vs Alternatives: Which Is Safer?
Official FDA Label for HYALURONIC ACID
Official prescribing information from the FDA-approved drug label.
FDA Approved Uses (Indications)
Take an appropriate amount of theproduct and gently dab it onto the forehead.cheeks, nose, and chin using your fingertips.Gently spread the moisturizer evenly overyour entire face with your fingertips
Dosage & Administration
It is generally used twice a day, in the morning and evening. Or use it whenever you need to clean your eyelids. - Wash your hands thoroughly before use. - Remove the pad after opening the packet. - Close your eyes and wipe the eyelids and the base of your eyelashes with cloth. - Once used, throw away cloth without fail.
Warnings
1. Consult a specialist if you have abnormal symptoms or side effects such as red spots, swelling, or itching due to direct sunlight during or after using this product. 2. Please refrain from using the wound area 3. Precautions for Storage and Handling A. Please keep it out of the reach of children. B. Please store it in a cool place. 4. Wash it immediately when it gets into your eyes.
Active Ingredient
MAGNESIUM CHLORIDE,SIMMONDSIA CHINENSIS (JOJOBA) SEED OIL,HYALURONIC ACID,VITIS VINIFERA (GRAPE) SEED OIL,TOCOPHEROL,LAVANDULA ANGUSTIFOLIA (LAVENDER) OIL
Inactive Ingredients
AQUA BUTYROSPERMUM PARKII (SHEA BUTTER) ALOE BARBADENSIS FLOWER EXTRACT SQUALANE COCOS NUCIFERA (COCONUT) OIL TREMELLA FUCIFORMIS POLYSACCHARIDE GLYCERIN ROSA MULTIFLORA FRUIT EXTRACT PANTHENOL SODIUM LACTATE BIOSACCHARIDE GUM-1 CHRYSANTHELLUM INDICUM EXTRACT PORTULACA OLERACEA EXTRACT HOUTTUYNIA CORDATA EXTRACT OPUNTIA TUNA FRUIT EXTRACT 1,2-HEXANEDIOL