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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

HYALURONIDASE \RITUXIMAB: 619 Adverse Event Reports & Safety Profile

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619
Total FAERS Reports
124 (20.0%)
Deaths Reported
189
Hospitalizations
619
As Primary/Secondary Suspect
108
Life-Threatening
154
Disabilities

First Report: 201204 · Latest Report: 20250909

What Are the Most Common HYALURONIDASE \RITUXIMAB Side Effects?

#1 Most Reported
Off label use
182 reports (29.4%)
#2 Most Reported
Fatigue
167 reports (27.0%)
#3 Most Reported
Drug ineffective
163 reports (26.3%)

All HYALURONIDASE \RITUXIMAB Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Off label use 182 29.4% 64 73
Fatigue 167 27.0% 78 108
Drug ineffective 163 26.3% 63 93
Alopecia 148 23.9% 78 107
Pain 146 23.6% 64 94
Maternal exposure during pregnancy 141 22.8% 82 108
Synovitis 140 22.6% 62 90
Hypertension 137 22.1% 71 100
Contraindicated product administered 136 22.0% 65 92
General physical health deterioration 136 22.0% 75 103
Hypersensitivity 136 22.0% 74 102
Arthralgia 135 21.8% 70 99
Abdominal discomfort 134 21.7% 77 105
Headache 134 21.7% 63 93
Rash 133 21.5% 63 66
Systemic lupus erythematosus 133 21.5% 69 98
Pemphigus 132 21.3% 68 97
Rheumatoid arthritis 131 21.2% 67 85
Pericarditis 130 21.0% 69 98
Arthropathy 129 20.8% 76 102

Who Reports HYALURONIDASE \RITUXIMAB Side Effects? Age & Gender Data

Gender: 72.3% female, 27.7% male. Average age: 58.0 years. Most reports from: US. View detailed demographics →

Is HYALURONIDASE \RITUXIMAB Getting Safer? Reports by Year

YearReportsDeathsHosp.
2012 2 0 1
2013 2 0 2
2014 5 4 4
2015 4 2 2
2016 2 0 0
2017 17 1 0
2018 25 1 5
2019 29 3 8
2020 17 2 8
2021 10 1 1
2022 13 3 3
2023 13 0 7
2024 3 1 0
2025 3 0 0

View full timeline →

What Is HYALURONIDASE \RITUXIMAB Used For?

IndicationReports
Product used for unknown indication 210
Rheumatoid arthritis 181
B-cell lymphoma 50
Diffuse large b-cell lymphoma 38
Non-hodgkin's lymphoma 28
Follicular lymphoma 17
Mantle cell lymphoma 15
Chronic lymphocytic leukaemia 13
Lymphoma 11
Antineutrophil cytoplasmic antibody 6

HYALURONIDASE \RITUXIMAB vs Alternatives: Which Is Safer?

HYALURONIDASE \RITUXIMAB vs HYALURONIDASE-ZZXF\PERTUZUMAB\TRASTUZUMAB HYALURONIDASE \RITUXIMAB vs HYDRALAZINE HYALURONIDASE \RITUXIMAB vs HYDRALAZINE\ISOSORBIDE DINITRATE HYALURONIDASE \RITUXIMAB vs HYDROCHLOROTHIAZIDE HYALURONIDASE \RITUXIMAB vs HYDROCHLOROTHIAZIDE\IRBESARTAN HYALURONIDASE \RITUXIMAB vs HYDROCHLOROTHIAZIDE\LISINOPRIL HYALURONIDASE \RITUXIMAB vs HYDROCHLOROTHIAZIDE\LOSARTAN HYALURONIDASE \RITUXIMAB vs HYDROCHLOROTHIAZIDE\METOPROLOL HYALURONIDASE \RITUXIMAB vs HYDROCHLOROTHIAZIDE\NEBIVOLOL HYALURONIDASE \RITUXIMAB vs HYDROCHLOROTHIAZIDE\OLMESARTAN MEDOXOMIL

Official FDA Label for HYALURONIDASE \RITUXIMAB

Official prescribing information from the FDA-approved drug label.