Skip to content
Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

LIDOCAINE\PRILOCAINE: 511 Adverse Event Reports & Safety Profile

Grow Your Own Natural Pharmacy at Home

Medicinal Garden Kit — 10 healing herbs, 4,818 seeds + step-by-step guide.

Get the Kit
511
Total FAERS Reports
8 (1.6%)
Deaths Reported
156
Hospitalizations
511
As Primary/Secondary Suspect
45
Life-Threatening
9
Disabilities

First Report: 19990101 · Latest Report: 20250728

What Are the Most Common LIDOCAINE\PRILOCAINE Side Effects?

#1 Most Reported
Drug ineffective
87 reports (17.0%)
#2 Most Reported
Methaemoglobinaemia
67 reports (13.1%)
#3 Most Reported
Therapy non-responder
53 reports (10.4%)

All LIDOCAINE\PRILOCAINE Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Drug ineffective 87 17.0% 1 16
Methaemoglobinaemia 67 13.1% 0 50
Therapy non-responder 53 10.4% 0 9
Immune thrombocytopenia 33 6.5% 0 0
Weight increased 33 6.5% 0 0
Dizziness 28 5.5% 0 21
Off label use 27 5.3% 1 17
Overdose 21 4.1% 1 11
Erythema 19 3.7% 0 6
Nausea 19 3.7% 0 13
Pain 18 3.5% 0 5
Toxicity to various agents 18 3.5% 1 13
Peritonitis 17 3.3% 0 17
Syncope 15 2.9% 0 6
Cyanosis 14 2.7% 0 10
Headache 14 2.7% 0 8
Therapy partial responder 14 2.7% 0 11
Drug ineffective for unapproved indication 13 2.5% 0 7
Infusion site pain 13 2.5% 0 6
Pruritus 13 2.5% 0 5

Who Reports LIDOCAINE\PRILOCAINE Side Effects? Age & Gender Data

Gender: 68.2% female, 31.8% male. Average age: 36.9 years. Most reports from: US. View detailed demographics →

Is LIDOCAINE\PRILOCAINE Getting Safer? Reports by Year

YearReportsDeathsHosp.
2012 1 0 0
2013 2 0 1
2014 10 0 0
2015 15 0 1
2016 8 0 1
2017 13 1 4
2018 27 0 3
2019 21 0 7
2020 22 1 8
2021 25 1 11
2022 22 0 6
2023 23 0 7
2024 16 0 12
2025 7 0 1

View full timeline →

What Is LIDOCAINE\PRILOCAINE Used For?

IndicationReports
Product used for unknown indication 146
Local anaesthesia 87
Complex regional pain syndrome 32
Pain 20
Anaesthesia 17
Infusion site pain 14
Injection site pain 13
Anaesthesia procedure 8
Circumcision 8
Neuralgia 6

LIDOCAINE\PRILOCAINE vs Alternatives: Which Is Safer?

LIDOCAINE\PRILOCAINE vs LIFILEUCEL LIDOCAINE\PRILOCAINE vs LIFITEGRAST LIDOCAINE\PRILOCAINE vs LIMAPROST LIDOCAINE\PRILOCAINE vs LINACLOTIDE LIDOCAINE\PRILOCAINE vs LINAGLIPTIN LIDOCAINE\PRILOCAINE vs LINAGLIPTIN\METFORMIN LIDOCAINE\PRILOCAINE vs LINCOMYCIN LIDOCAINE\PRILOCAINE vs LINEZOLID LIDOCAINE\PRILOCAINE vs LINZESS LIDOCAINE\PRILOCAINE vs LIORESAL

Official FDA Label for LIDOCAINE\PRILOCAINE

Official prescribing information from the FDA-approved drug label.