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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

LOPRAZOLAM: 331 Adverse Event Reports & Safety Profile

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331
Total FAERS Reports
36 (10.9%)
Deaths Reported
183
Hospitalizations
331
As Primary/Secondary Suspect
82
Life-Threatening

First Report: 20090505 · Latest Report: 20250601

What Are the Most Common LOPRAZOLAM Side Effects?

#1 Most Reported
Coma
79 reports (23.9%)
#2 Most Reported
Toxicity to various agents
48 reports (14.5%)
#3 Most Reported
Somnolence
45 reports (13.6%)

All LOPRAZOLAM Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Coma 79 23.9% 2 48
Toxicity to various agents 48 14.5% 5 27
Somnolence 45 13.6% 6 24
Hypotension 25 7.6% 2 16
Rhabdomyolysis 24 7.3% 0 11
Miosis 21 6.3% 5 6
Drug abuse 20 6.0% 0 6
Intentional overdose 19 5.7% 1 13
Overdose 18 5.4% 0 17
Poisoning deliberate 17 5.1% 2 13
Death 16 4.8% 16 1
Bradypnoea 14 4.2% 0 14
Acute kidney injury 11 3.3% 0 2
Pneumonia aspiration 11 3.3% 0 1
Suicide attempt 11 3.3% 0 8
Bundle branch block right 10 3.0% 0 9
Disorientation 10 3.0% 0 10
Lactic acidosis 10 3.0% 1 1
Alanine aminotransferase increased 9 2.7% 0 0
Blood bilirubin increased 9 2.7% 0 0

Who Reports LOPRAZOLAM Side Effects? Age & Gender Data

Gender: 58.8% female, 41.2% male. Average age: 53.0 years. Most reports from: FR. View detailed demographics →

Is LOPRAZOLAM Getting Safer? Reports by Year

YearReportsDeathsHosp.
2009 2 0 0
2010 1 0 1
2013 7 6 1
2014 23 1 21
2015 7 3 6
2016 13 0 11
2017 30 2 19
2018 60 6 43
2019 11 0 11
2020 14 0 1
2021 19 7 8
2022 15 2 8
2023 25 0 8
2024 5 0 1
2025 4 0 4

View full timeline →

What Is LOPRAZOLAM Used For?

IndicationReports
Product used for unknown indication 129
Insomnia 32
Poisoning deliberate 19
Sleep disorder 18
Suicide attempt 14
Toxicity to various agents 14
Depression 11
Intentional overdose 8
Schizoaffective disorder 8
Drug abuse 6

LOPRAZOLAM vs Alternatives: Which Is Safer?

LOPRAZOLAM vs LORATADINE LOPRAZOLAM vs LORATADINE\PSEUDOEPHEDRINE LOPRAZOLAM vs LORAZEPAM LOPRAZOLAM vs LORCASERIN LOPRAZOLAM vs LORLATINIB LOPRAZOLAM vs LORMETAZEPAM LOPRAZOLAM vs LORNOXICAM LOPRAZOLAM vs LOSARTAN LOPRAZOLAM vs LOSARTAN\LOSARTAN LOPRAZOLAM vs LOTEPREDNOL ETABONATE

Official FDA Label for LOPRAZOLAM

Official prescribing information from the FDA-approved drug label.