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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

METAMIZOLE: 5,622 Adverse Event Reports & Safety Profile

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5,622
Total FAERS Reports
821 (14.6%)
Deaths Reported
3,361
Hospitalizations
5,622
As Primary/Secondary Suspect
938
Life-Threatening
339
Disabilities

First Report: 19920906 · Latest Report: 20250816

What Are the Most Common METAMIZOLE Side Effects?

#1 Most Reported
Nausea
451 reports (8.0%)
#2 Most Reported
Agranulocytosis
438 reports (7.8%)
#3 Most Reported
Vomiting
410 reports (7.3%)

All METAMIZOLE Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Nausea 451 8.0% 121 319
Agranulocytosis 438 7.8% 75 341
Vomiting 410 7.3% 108 322
Off label use 370 6.6% 167 228
Drug ineffective 352 6.3% 78 245
Pyrexia 322 5.7% 46 266
Dyspnoea 316 5.6% 80 195
General physical health deterioration 307 5.5% 121 248
Pain 281 5.0% 34 198
Abdominal pain 278 4.9% 107 208
Somnolence 260 4.6% 103 159
Condition aggravated 259 4.6% 102 191
Toxic epidermal necrolysis 226 4.0% 87 117
Sepsis 224 4.0% 150 162
Constipation 215 3.8% 101 145
Rash 213 3.8% 31 133
Drug interaction 209 3.7% 32 179
Headache 207 3.7% 16 169
Angioedema 203 3.6% 0 8
Pneumonia 200 3.6% 74 171

Who Reports METAMIZOLE Side Effects? Age & Gender Data

Gender: 55.9% female, 44.1% male. Average age: 56.4 years. Most reports from: DE. View detailed demographics →

Is METAMIZOLE Getting Safer? Reports by Year

YearReportsDeathsHosp.
2000 35 2 11
2001 22 0 17
2002 2 0 1
2003 4 1 2
2004 12 2 1
2005 11 6 11
2006 15 1 13
2007 6 0 6
2008 6 0 6
2009 48 6 16
2010 21 0 16
2011 22 3 15
2012 25 4 18
2013 38 3 28
2014 98 4 64
2015 198 36 156
2016 172 19 135
2017 301 31 192
2018 313 36 200
2019 339 33 232
2020 343 101 217
2021 249 40 151
2022 180 9 133
2023 275 38 158
2024 207 17 143
2025 72 9 50

View full timeline →

What Is METAMIZOLE Used For?

IndicationReports
Product used for unknown indication 2,344
Pain 866
Analgesic therapy 254
Pyrexia 161
Vitamin supplementation 157
Back pain 121
Arthralgia 71
Intentional product misuse 66
Migraine 63
Headache 61

METAMIZOLE vs Alternatives: Which Is Safer?

METAMIZOLE vs METARAMINOL METAMIZOLE vs METAXALONE METAMIZOLE vs METFORMIN METAMIZOLE vs METFORMIN\PIOGLITAZONE METAMIZOLE vs METFORMIN\ROSIGLITAZONE METAMIZOLE vs METFORMIN\SAXAGLIPTIN METAMIZOLE vs METFORMIN\SITAGLIPTIN METAMIZOLE vs METFORMIN\VILDAGLIPTIN METAMIZOLE vs METHADONE METAMIZOLE vs METHAMPHETAMINE

Official FDA Label for METAMIZOLE

Official prescribing information from the FDA-approved drug label.