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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

METFORMIN\PIOGLITAZONE: 506 Adverse Event Reports & Safety Profile

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506
Total FAERS Reports
68 (13.4%)
Deaths Reported
91
Hospitalizations
506
As Primary/Secondary Suspect
20
Life-Threatening
1
Disabilities

Active Ingredient: METFORMIN HYDROCHLORIDE\PIOGLITAZONE HYDROCHLORIDE ·

First Report: 200012 · Latest Report: 20250604

What Are the Most Common METFORMIN\PIOGLITAZONE Side Effects?

#1 Most Reported
Bladder cancer
278 reports (54.9%)
#2 Most Reported
Death
45 reports (8.9%)
#3 Most Reported
Hypoglycaemia
27 reports (5.3%)

All METFORMIN\PIOGLITAZONE Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Bladder cancer 278 54.9% 51 2
Death 45 8.9% 45 0
Hypoglycaemia 27 5.3% 1 15
Bladder transitional cell carcinoma 17 3.4% 2 2
Lactic acidosis 15 3.0% 1 7
Sopor 13 2.6% 0 9
Bladder cancer recurrent 11 2.2% 5 1
Drug abuse 11 2.2% 0 9
Pneumonia 11 2.2% 0 11
Atrial fibrillation 10 2.0% 0 10
Peripheral swelling 10 2.0% 0 8
Drug ineffective 9 1.8% 0 4
Haematuria 9 1.8% 2 2
Blood glucose increased 8 1.6% 2 3
Crying 8 1.6% 0 8
Prostate cancer 8 1.6% 1 0
Urinary tract infection 8 1.6% 2 1
Diarrhoea 7 1.4% 1 2
Metabolic acidosis 7 1.4% 0 7
Off label use 7 1.4% 1 4

Who Reports METFORMIN\PIOGLITAZONE Side Effects? Age & Gender Data

Gender: 38.4% female, 61.6% male. Average age: 66.3 years. Most reports from: US. View detailed demographics →

Is METFORMIN\PIOGLITAZONE Getting Safer? Reports by Year

YearReportsDeathsHosp.
2000 1 0 0
2001 1 0 0
2003 1 0 0
2004 2 0 0
2005 6 0 0
2006 8 3 0
2007 13 5 0
2008 23 7 0
2009 37 10 3
2010 41 11 4
2011 66 13 1
2012 55 10 3
2013 40 2 0
2014 29 1 13
2015 17 1 4
2016 17 0 5
2017 8 1 4
2018 6 1 2
2019 11 0 5
2020 18 0 7
2021 5 0 2
2022 5 0 5
2023 4 0 4
2024 3 0 2
2025 5 0 4

View full timeline →

What Is METFORMIN\PIOGLITAZONE Used For?

IndicationReports
Type 2 diabetes mellitus 345
Diabetes mellitus 73
Product used for unknown indication 47
Drug abuse 6

METFORMIN\PIOGLITAZONE vs Alternatives: Which Is Safer?

METFORMIN\PIOGLITAZONE vs METFORMIN\ROSIGLITAZONE METFORMIN\PIOGLITAZONE vs METFORMIN\SAXAGLIPTIN METFORMIN\PIOGLITAZONE vs METFORMIN\SITAGLIPTIN METFORMIN\PIOGLITAZONE vs METFORMIN\VILDAGLIPTIN METFORMIN\PIOGLITAZONE vs METHADONE METFORMIN\PIOGLITAZONE vs METHAMPHETAMINE METFORMIN\PIOGLITAZONE vs METHENAMINE HIPPURATE METFORMIN\PIOGLITAZONE vs METHIMAZOLE METFORMIN\PIOGLITAZONE vs METHOCARBAMOL METFORMIN\PIOGLITAZONE vs METHOHEXITAL

Official FDA Label for METFORMIN\PIOGLITAZONE

Official prescribing information from the FDA-approved drug label.