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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

METFORMIN\SITAGLIPTIN: 8,810 Adverse Event Reports & Safety Profile

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8,810
Total FAERS Reports
1,110 (12.6%)
Deaths Reported
2,869
Hospitalizations
8,810
As Primary/Secondary Suspect
678
Life-Threatening
242
Disabilities

Active Ingredient: METFORMIN HYDROCHLORIDE\SITAGLIPTIN PHOSPHATE ·

First Report: 1992 · Latest Report: 20250828

What Are the Most Common METFORMIN\SITAGLIPTIN Side Effects?

#1 Most Reported
Blood glucose increased
709 reports (8.0%)
#2 Most Reported
Acute kidney injury
616 reports (7.0%)
#3 Most Reported
Lactic acidosis
557 reports (6.3%)

All METFORMIN\SITAGLIPTIN Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Blood glucose increased 709 8.1% 17 150
Acute kidney injury 616 7.0% 93 422
Lactic acidosis 557 6.3% 132 313
No adverse event 539 6.1% 0 1
Diarrhoea 513 5.8% 24 152
Inappropriate schedule of drug administration 469 5.3% 113 186
Product dose omission issue 452 5.1% 0 21
Pancreatic carcinoma 431 4.9% 280 125
Drug ineffective 384 4.4% 31 57
Nausea 378 4.3% 40 118
Diabetes mellitus inadequate control 364 4.1% 40 70
Vomiting 343 3.9% 32 168
Pancreatitis 307 3.5% 57 203
Weight decreased 284 3.2% 17 101
Death 248 2.8% 247 86
Inappropriate schedule of product administration 245 2.8% 11 51
Hypoglycaemia 240 2.7% 56 123
Hyperglycaemia 236 2.7% 15 88
Hyperkalaemia 233 2.6% 41 87
Gastrooesophageal reflux disease 226 2.6% 59 89

Who Reports METFORMIN\SITAGLIPTIN Side Effects? Age & Gender Data

Gender: 50.5% female, 49.5% male. Average age: 65.4 years. Most reports from: US. View detailed demographics →

Is METFORMIN\SITAGLIPTIN Getting Safer? Reports by Year

YearReportsDeathsHosp.
2000 1 0 0
2002 3 0 0
2004 1 0 1
2005 1 0 0
2006 4 1 3
2007 26 21 16
2008 43 27 27
2009 48 31 30
2010 72 35 45
2011 97 66 62
2012 174 83 74
2013 271 102 102
2014 506 99 224
2015 683 103 318
2016 527 85 221
2017 486 44 172
2018 509 75 151
2019 463 38 182
2020 445 11 170
2021 352 18 133
2022 277 22 89
2023 234 18 102
2024 175 7 71
2025 99 5 45

View full timeline →

What Is METFORMIN\SITAGLIPTIN Used For?

IndicationReports
Diabetes mellitus 2,606
Type 2 diabetes mellitus 2,471
Product used for unknown indication 825
Blood glucose increased 51
Blood glucose abnormal 47
Diabetes mellitus management 41
Insulin-requiring type 2 diabetes mellitus 29
Blood glucose 28
Type 1 diabetes mellitus 28
Glycosylated haemoglobin increased 20

METFORMIN\SITAGLIPTIN vs Alternatives: Which Is Safer?

METFORMIN\SITAGLIPTIN vs METFORMIN\VILDAGLIPTIN METFORMIN\SITAGLIPTIN vs METHADONE METFORMIN\SITAGLIPTIN vs METHAMPHETAMINE METFORMIN\SITAGLIPTIN vs METHENAMINE HIPPURATE METFORMIN\SITAGLIPTIN vs METHIMAZOLE METFORMIN\SITAGLIPTIN vs METHOCARBAMOL METFORMIN\SITAGLIPTIN vs METHOHEXITAL METFORMIN\SITAGLIPTIN vs METHOTREXATE METFORMIN\SITAGLIPTIN vs METHOXSALEN METFORMIN\SITAGLIPTIN vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA

Official FDA Label for METFORMIN\SITAGLIPTIN

Official prescribing information from the FDA-approved drug label.