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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

METHOTREXATE: Side Effect Reports by Year

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Year-by-year breakdown of FAERS adverse event reports for METHOTREXATE. Total: 253,987 reports.

Year Reports Deaths Hospitalizations Death Rate
2000 99 15 17 15.2%
2001 86 12 23 14.0%
2002 67 4 27 6.0%
2003 127 7 56 5.5%
2004 139 23 48 16.5%
2005 152 6 54 3.9%
2006 242 23 85 9.5%
2007 306 15 119 4.9%
2008 522 57 171 10.9%
2009 510 42 196 8.2%
2010 753 68 321 9.0%
2011 863 73 352 8.5%
2012 1,265 100 474 7.9%
2013 2,309 194 986 8.4%
2014 4,102 300 1,916 7.3%
2015 5,322 353 2,457 6.6%
2016 6,138 450 2,893 7.3%
2017 9,575 568 4,610 5.9%
2018 7,712 556 3,898 7.2%
2019 6,689 550 3,721 8.2%
2020 5,500 507 3,042 9.2%
2021 4,916 449 2,720 9.1%
2022 4,856 331 2,613 6.8%
2023 4,051 250 1,968 6.2%
2024 3,020 160 1,554 5.3%
2025 1,222 101 680 8.3%
Total 253,987 21,265 68,793 8.4%

FDA approval date: Approved Prior to Jan 1, 1982.

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