NIACINAMIDE: 1,283 Adverse Event Reports & Safety Profile
Drink Less in 7 Days — Without Willpower
Clinically proven audio program. Just 25 min/day. Already helped 108,000+ people.
Route: TOPICAL · Manufacturer: Jiangxi Yudexi Pharmaceutical Co., LTD · HUMAN OTC DRUG · FDA Label: Available
First Report: 2006 · Latest Report: 20250611
What Are the Most Common NIACINAMIDE Side Effects?
All NIACINAMIDE Side Effects by Frequency
| Side Effect | Reports | % of Total | Deaths | Hosp. |
|---|---|---|---|---|
| Off label use | 540 | 42.1% | 263 | 465 |
| Drug ineffective | 436 | 34.0% | 189 | 345 |
| Pain | 405 | 31.6% | 244 | 390 |
| Nausea | 380 | 29.6% | 226 | 374 |
| Infusion related reaction | 325 | 25.3% | 188 | 321 |
| Malaise | 324 | 25.3% | 168 | 320 |
| Gastrooesophageal reflux disease | 311 | 24.2% | 149 | 299 |
| Dyspepsia | 310 | 24.2% | 160 | 289 |
| Headache | 283 | 22.1% | 150 | 280 |
| Condition aggravated | 256 | 20.0% | 198 | 210 |
| Therapeutic product effect incomplete | 247 | 19.3% | 57 | 224 |
| Product use in unapproved indication | 241 | 18.8% | 192 | 201 |
| Dyspnoea | 235 | 18.3% | 202 | 216 |
| Maternal exposure during pregnancy | 227 | 17.7% | 179 | 177 |
| Drug intolerance | 219 | 17.1% | 182 | 182 |
| Pemphigus | 217 | 16.9% | 208 | 206 |
| Swelling | 214 | 16.7% | 213 | 211 |
| Rash | 213 | 16.6% | 210 | 211 |
| Lung disorder | 209 | 16.3% | 194 | 205 |
| Onychomadesis | 206 | 16.1% | 206 | 205 |
Who Reports NIACINAMIDE Side Effects? Age & Gender Data
Gender: 77.0% female, 23.0% male. Average age: 55.0 years. Most reports from: CA. View detailed demographics →
Is NIACINAMIDE Getting Safer? Reports by Year
| Year | Reports | Deaths | Hosp. |
|---|---|---|---|
| 2006 | 14 | 0 | 0 |
| 2013 | 1 | 0 | 1 |
| 2014 | 4 | 0 | 3 |
| 2015 | 19 | 8 | 16 |
| 2016 | 4 | 2 | 2 |
| 2017 | 21 | 1 | 18 |
| 2018 | 29 | 4 | 18 |
| 2019 | 14 | 0 | 9 |
| 2020 | 31 | 7 | 8 |
| 2021 | 5 | 1 | 1 |
| 2022 | 4 | 0 | 0 |
| 2023 | 7 | 0 | 2 |
| 2024 | 9 | 0 | 8 |
| 2025 | 1 | 0 | 0 |
What Is NIACINAMIDE Used For?
| Indication | Reports |
|---|---|
| Product used for unknown indication | 957 |
| Foetal exposure during pregnancy | 58 |
| Pemphigoid | 52 |
| Vitamin supplementation | 20 |
| Hypovitaminosis | 15 |
| Pemphigus | 11 |
| Ill-defined disorder | 10 |
| Alcoholism | 7 |
| Granuloma annulare | 5 |
NIACINAMIDE vs Alternatives: Which Is Safer?
Official FDA Label for NIACINAMIDE
Official prescribing information from the FDA-approved drug label.
FDA Approved Uses (Indications)
Effect: with a refreshing andradiant texture,it has a delicatetouch thatiseasy toandst oothabsorb .ltreplenishesthenecessanmoistureandnutrients for the skin,improvesdryness ,wrinkles and firming.reduces fine lines,providesintensivecare,lifts and solidifiesthe skin leaving it soft,smooth.and radiant with youthfulradiance
Dosage & Administration
Usage: After cleansing and toningtake an appropriate amount of thisproduct and pour it into the palm ofyour hand to evenly apply to the face or neck .Gently massage until absorbed
Warnings
WARNINGS Warnings: 1. In case of having following symptoms after using this, you're advised to stop using it immediately. If you keep using it, the symptoms will get worse and need to consult a dermatologist 1) In case of having problems such as red rash, swollenness, itching, stimulation during usage 2) In case of having the same symptoms above on the part you put this product on by direct sunlight 2. You are banned to use it on the part where you have a scar, eczema, or dermatitis 3. In case of getting it into your eyes, you have to wash it immediately 4. Caution for treatment and keeping 1) Tighten the lid after using it 2) Keep it out of infants or children's reach 3) Don't keep it in the place where the temperature is extremely hot or low and exposed to the direct sunlight
Active Ingredient
Curcumins2% Acne HYDROLYZED COLLAGEN EXTRACT2% Moisturize NIACINAMIDE2% Moisturize
Inactive Ingredients
INACTIVE INGREDIENT Inactive ingredients: Water, Glycerin, Butylene Glycol, 1,2-Hexanediol, Polyglyceryl-10 Oleate, Silk Amino Acids, Angelica Dahurica Root Extract, Cimicifuga Dahurica Root Extract, Bletia Hyacinthina Bulb Extract, Oryza Sativa (Rice) Extract, Phaseolus Radiatus Seed Extract, Trichosanthes Kirilowii Root Extract, Amomum Xanthioides Seed Extract, Broussonetia Kazinoki Root Extract, Eugenia Caryophyllus (Clove)
Flower
Extract, Sodium Hyaluronate, Allantoin, Rehmannia Chinensis Root Extract, Poria Cocos Extract, Panax Ginseng Root Extract, Honey Extract, Pentylene Glycol, Glyceryl Acrylate/Acrylic Acid Copolymer, Ethylhexylglycerin, Phenoxyethanol, Hydrogenated Lecithin, Caprylyl glycol, Camellia Japonica Seed Oil, Disodium EDTA, Sucrose Palmitate, Citrus Aurantium Bergamia (Bergamot)
Fruit
Oil, Hydrogenated Lecithin, Aniba Rosodora (Rosewood)
Wood
Oil, Santalum Album (Sandalwood) Oil, Melaleuca Alternifolia (Tea Tree)
Leaf
Oil, Citrus Limon (Lemon)
Peel
Oil, Olea Europaea (Olive)
Fruit
Oil, Macadamia Integrifolia Seed Oil, Vitis Vinifera (Grape)
Seed
Oil, Simmondsia Chinensis (Jojoba)
Seed
Oil, Sodium Hyaluronate Crosspolymer, Hyaluronic Acid, Hydrolyzed Sodium Hyaluronate, Palmitoyl Hexapeptide-12, Hydrolyzed Hyaluronic Acid