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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

PEGINTERFERON ALFA-2B: 4,226 Adverse Event Reports & Safety Profile

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4,226
Total FAERS Reports
184 (4.4%)
Deaths Reported
978
Hospitalizations
4,226
As Primary/Secondary Suspect
129
Life-Threatening
99
Disabilities
Prescription
Status

FDA Application: 103949 ·

First Report: 1994 · Latest Report: 20250805

What Are the Most Common PEGINTERFERON ALFA-2B Side Effects?

#1 Most Reported
Anaemia
804 reports (19.0%)
#2 Most Reported
Platelet count decreased
593 reports (14.0%)
#3 Most Reported
Pyrexia
440 reports (10.4%)

All PEGINTERFERON ALFA-2B Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Anaemia 804 19.0% 37 184
Platelet count decreased 593 14.0% 13 96
Pyrexia 440 10.4% 11 89
White blood cell count decreased 420 9.9% 8 61
Haemoglobin decreased 281 6.7% 10 70
Neutrophil count decreased 272 6.4% 7 43
Nausea 269 6.4% 6 80
Rash 269 6.4% 20 60
Fatigue 245 5.8% 4 44
Decreased appetite 224 5.3% 7 65
Blood bilirubin increased 222 5.3% 3 31
Malaise 219 5.2% 13 53
Headache 207 4.9% 7 56
Neutropenia 194 4.6% 21 53
No adverse event 190 4.5% 0 0
Pruritus 182 4.3% 4 35
Thrombocytopenia 167 4.0% 23 49
Product quality issue 159 3.8% 1 11
Depression 152 3.6% 10 44
Drug ineffective 152 3.6% 7 26

Who Reports PEGINTERFERON ALFA-2B Side Effects? Age & Gender Data

Gender: 48.1% female, 51.9% male. Average age: 57.8 years. Most reports from: JP. View detailed demographics →

Is PEGINTERFERON ALFA-2B Getting Safer? Reports by Year

YearReportsDeathsHosp.
2000 2 0 2
2001 2 0 0
2002 6 0 1
2003 9 0 4
2004 18 0 15
2005 19 0 3
2006 13 0 2
2007 28 0 5
2008 23 0 1
2009 21 2 5
2010 18 0 5
2011 32 3 15
2012 376 11 162
2013 214 12 113
2014 1,427 43 293
2015 227 10 77
2016 120 2 38
2017 54 7 23
2018 35 2 8
2019 17 0 5
2020 9 0 3
2021 1 0 0
2022 1 0 0
2023 5 0 2
2024 4 0 1
2025 9 0 0

View full timeline →

What Is PEGINTERFERON ALFA-2B Used For?

IndicationReports
Chronic hepatitis c 1,927
Hepatitis c 1,246
Malignant melanoma 134
Product used for unknown indication 122
Hepatic cirrhosis 91
Chronic myeloid leukaemia 53
Chronic hepatitis b 32
Hepatitis c virus test positive 20
Hiv infection 15
Essential thrombocythaemia 14

PEGINTERFERON ALFA-2B vs Alternatives: Which Is Safer?

PEGINTERFERON ALFA-2B vs PEGINTERFERON BETA-1A PEGINTERFERON ALFA-2B vs PEGINTRON PEGINTERFERON ALFA-2B vs PEGLOTICASE PEGINTERFERON ALFA-2B vs PEGUNIGALSIDASE ALFA-IWXJ PEGINTERFERON ALFA-2B vs PEGVALIASE-PQPZ PEGINTERFERON ALFA-2B vs PEGVISOMANT PEGINTERFERON ALFA-2B vs PEGZEREPOETIN ALFA PEGINTERFERON ALFA-2B vs PEMBROLIZUMAB PEGINTERFERON ALFA-2B vs PEMETREXED PEGINTERFERON ALFA-2B vs PEMIGATINIB

Official FDA Label for PEGINTERFERON ALFA-2B

Official prescribing information from the FDA-approved drug label.