PEGVALIASE-PQPZ: 7,362 Adverse Event Reports & Safety Profile
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7,362
Total FAERS Reports
12 (0.2%)
Deaths Reported
251
Hospitalizations
7,362
As Primary/Secondary Suspect
71
Life-Threatening
4
Disabilities
Prescription
Status
FDA Application: 761079 ·
First Report: 20020628 · Latest Report: 20250924
What Are the Most Common PEGVALIASE-PQPZ Side Effects?
#1 Most Reported
Arthralgia
1,289 reports (17.5%)
#2 Most Reported
Injection site reaction
835 reports (11.3%)
#3 Most Reported
Injection site erythema
678 reports (9.2%)
All PEGVALIASE-PQPZ Side Effects by Frequency
| Side Effect | Reports | % of Total | Deaths | Hosp. |
|---|---|---|---|---|
| Arthralgia | 1,289 | 17.5% | 0 | 15 |
| Injection site reaction | 835 | 11.3% | 0 | 4 |
| Injection site erythema | 678 | 9.2% | 0 | 3 |
| Injection site swelling | 498 | 6.8% | 0 | 1 |
| Rash | 460 | 6.3% | 0 | 11 |
| Urticaria | 460 | 6.3% | 0 | 15 |
| Headache | 403 | 5.5% | 0 | 5 |
| Injection site pain | 388 | 5.3% | 0 | 1 |
| Fatigue | 348 | 4.7% | 0 | 8 |
| Injection site pruritus | 331 | 4.5% | 0 | 3 |
| Pruritus | 312 | 4.2% | 0 | 4 |
| Hypersensitivity | 310 | 4.2% | 0 | 11 |
| Dizziness | 297 | 4.0% | 0 | 21 |
| Dyspnoea | 290 | 3.9% | 1 | 45 |
| Nausea | 284 | 3.9% | 0 | 22 |
| Anaphylactic reaction | 282 | 3.8% | 0 | 36 |
| Off label use | 271 | 3.7% | 0 | 8 |
| Vomiting | 216 | 2.9% | 0 | 22 |
| Pyrexia | 207 | 2.8% | 0 | 16 |
| Injection site bruising | 196 | 2.7% | 0 | 1 |
Who Reports PEGVALIASE-PQPZ Side Effects? Age & Gender Data
Gender: 61.2% female, 38.8% male. Average age: 32.3 years. Most reports from: US. View detailed demographics →
Is PEGVALIASE-PQPZ Getting Safer? Reports by Year
| Year | Reports | Deaths | Hosp. |
|---|---|---|---|
| 2002 | 1 | 0 | 0 |
| 2015 | 1 | 0 | 0 |
| 2018 | 144 | 0 | 4 |
| 2019 | 534 | 0 | 16 |
| 2020 | 586 | 1 | 24 |
| 2021 | 438 | 1 | 34 |
| 2022 | 303 | 1 | 28 |
| 2023 | 374 | 2 | 33 |
| 2024 | 337 | 3 | 27 |
| 2025 | 254 | 0 | 18 |
What Is PEGVALIASE-PQPZ Used For?
| Indication | Reports |
|---|---|
| Phenylketonuria | 5,436 |
| Product used for unknown indication | 1,903 |
| Hyperphenylalaninaemia | 29 |
| Foetal exposure during pregnancy | 9 |
PEGVALIASE-PQPZ vs Alternatives: Which Is Safer?
PEGVALIASE-PQPZ vs PEGVISOMANT
PEGVALIASE-PQPZ vs PEGZEREPOETIN ALFA
PEGVALIASE-PQPZ vs PEMBROLIZUMAB
PEGVALIASE-PQPZ vs PEMETREXED
PEGVALIASE-PQPZ vs PEMIGATINIB
PEGVALIASE-PQPZ vs PENICILLAMINE
PEGVALIASE-PQPZ vs PENICILLIN
PEGVALIASE-PQPZ vs PENICILLIN G
PEGVALIASE-PQPZ vs PENICILLIN G BENZATHINE
PEGVALIASE-PQPZ vs PENICILLIN G PROCAINE
Official FDA Label for PEGVALIASE-PQPZ
Official prescribing information from the FDA-approved drug label.