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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

PENICILLIN: 2,040 Adverse Event Reports & Safety Profile

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2,040
Total FAERS Reports
66 (3.2%)
Deaths Reported
411
Hospitalizations
2,040
As Primary/Secondary Suspect
76
Life-Threatening
23
Disabilities

First Report: 19630101 · Latest Report: 20250901

What Are the Most Common PENICILLIN Side Effects?

#1 Most Reported
Drug hypersensitivity
875 reports (42.9%)
#2 Most Reported
Rash
392 reports (19.2%)
#3 Most Reported
Urticaria
296 reports (14.5%)

All PENICILLIN Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Drug hypersensitivity 875 42.9% 6 171
Rash 392 19.2% 2 73
Urticaria 296 14.5% 0 24
Pruritus 203 10.0% 5 42
Diarrhoea 201 9.9% 2 63
Hypersensitivity 188 9.2% 2 43
Drug ineffective 179 8.8% 6 52
Nausea 178 8.7% 3 77
Fatigue 158 7.8% 1 56
Malaise 149 7.3% 1 53
Dizziness 148 7.3% 0 35
Dyspnoea 147 7.2% 6 71
Abdominal pain upper 129 6.3% 0 41
Vomiting 128 6.3% 3 36
Arthralgia 125 6.1% 0 55
Headache 121 5.9% 2 48
Pain 121 5.9% 1 66
Pneumonia 120 5.9% 3 32
Anaphylactic reaction 118 5.8% 3 22
Anxiety 100 4.9% 2 22

Who Reports PENICILLIN Side Effects? Age & Gender Data

Gender: 76.1% female, 23.9% male. Average age: 50.1 years. Most reports from: US. View detailed demographics →

Is PENICILLIN Getting Safer? Reports by Year

YearReportsDeathsHosp.
2000 6 0 4
2001 3 0 0
2002 3 0 0
2003 1 0 0
2004 1 0 0
2006 18 0 11
2007 9 2 4
2008 12 0 0
2009 1 0 1
2010 6 0 1
2011 5 0 2
2012 11 0 5
2013 27 1 16
2014 48 2 20
2015 39 0 25
2016 42 0 20
2017 40 0 12
2018 41 1 18
2019 34 0 16
2020 18 2 7
2021 22 3 10
2022 29 2 11
2023 28 0 9
2024 28 2 13
2025 10 0 4

View full timeline →

What Is PENICILLIN Used For?

IndicationReports
Product used for unknown indication 1,313
Prophylaxis 28
Tonsillitis 19
Pharyngitis streptococcal 18
Antibiotic therapy 12
Tooth infection 11
Infection 10
Psoriasis 10
Brain abscess 9
Meningococcal infection 8

PENICILLIN vs Alternatives: Which Is Safer?

PENICILLIN vs PENICILLIN G PENICILLIN vs PENICILLIN G BENZATHINE PENICILLIN vs PENICILLIN G PROCAINE PENICILLIN vs PENICILLIN V PENICILLIN vs PENICILLIN V BENZATHINE PENICILLIN vs PENTAMIDINE PENICILLIN vs PENTAMIDINE ISETHIONATE PENICILLIN vs PENTAZOCINE PENICILLIN vs PENTOBARBITAL PENICILLIN vs PENTOSAN POLYSULFATE

Official FDA Label for PENICILLIN

Official prescribing information from the FDA-approved drug label.