Skip to content
Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

PHENTERMINE\TOPIRAMATE: 5,389 Adverse Event Reports & Safety Profile

Lose Weight Fast — The 21-Day Smoothie Diet

36 fat-burning recipes + shopping lists. Results in the first week.

Get the Program
5,389
Total FAERS Reports
9 (0.2%)
Deaths Reported
170
Hospitalizations
5,389
As Primary/Secondary Suspect
23
Life-Threatening
41
Disabilities

Active Ingredient: PHENTERMINE HYDROCHLORIDE\TOPIRAMATE ·

First Report: 2011 · Latest Report: 20250728

What Are the Most Common PHENTERMINE\TOPIRAMATE Side Effects?

#1 Most Reported
Headache
333 reports (6.2%)
#2 Most Reported
Paraesthesia
309 reports (5.7%)
#3 Most Reported
Insomnia
274 reports (5.1%)

All PHENTERMINE\TOPIRAMATE Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Headache 333 6.2% 0 3
Paraesthesia 309 5.7% 0 4
Insomnia 274 5.1% 0 5
Dry mouth 264 4.9% 0 2
Weight increased 250 4.6% 0 3
Dizziness 245 4.6% 0 4
Feeling abnormal 210 3.9% 0 0
Fatigue 194 3.6% 0 8
Inappropriate schedule of product administration 194 3.6% 0 0
Constipation 188 3.5% 0 5
Anxiety 177 3.3% 0 5
Nausea 176 3.3% 0 2
Alopecia 166 3.1% 0 0
Vision blurred 146 2.7% 0 4
Palpitations 145 2.7% 0 2
Depression 139 2.6% 0 6
Product dose omission issue 138 2.6% 0 0
Hypoaesthesia 133 2.5% 0 5
Malaise 120 2.2% 0 4
Dysgeusia 115 2.1% 0 2

Who Reports PHENTERMINE\TOPIRAMATE Side Effects? Age & Gender Data

Gender: 88.3% female, 11.7% male. Average age: 49.8 years. Most reports from: US. View detailed demographics →

Is PHENTERMINE\TOPIRAMATE Getting Safer? Reports by Year

YearReportsDeathsHosp.
2011 1 0 0
2012 6 0 1
2013 65 2 16
2014 271 0 28
2015 292 0 15
2016 177 0 6
2017 127 1 6
2018 72 0 6
2019 96 1 2
2020 112 0 7
2021 145 0 4
2022 121 0 8
2023 96 0 8
2024 75 0 4
2025 43 0 1

View full timeline →

What Is PHENTERMINE\TOPIRAMATE Used For?

IndicationReports
Product used for unknown indication 3,044
Weight decreased 2,129
Obesity 86
Weight control 21
Migraine 16
Diabetes mellitus 5
Overweight 5
Weight increased 5

PHENTERMINE\TOPIRAMATE vs Alternatives: Which Is Safer?

PHENTERMINE\TOPIRAMATE vs PHENTOLAMINE PHENTERMINE\TOPIRAMATE vs PHENYLEPHRINE PHENTERMINE\TOPIRAMATE vs PHENYLEPHRINE\PHENYLEPHRINE PHENTERMINE\TOPIRAMATE vs PHENYLPROPANOLAMINE PHENTERMINE\TOPIRAMATE vs PHENYTOIN PHENTERMINE\TOPIRAMATE vs PHLEUM PRATENSE POLLEN PHENTERMINE\TOPIRAMATE vs PHLOROGLUCINOL PHENTERMINE\TOPIRAMATE vs PHLOROGLUCINOL\1,3,5-TRIMETHOXYBENZENE PHENTERMINE\TOPIRAMATE vs PHOLCODINE PHENTERMINE\TOPIRAMATE vs PHOSPHORUS

Official FDA Label for PHENTERMINE\TOPIRAMATE

Official prescribing information from the FDA-approved drug label.