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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

PIPERACILLIN\TAZOBACTAM: 19,172 Adverse Event Reports & Safety Profile

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19,172
Total FAERS Reports
3,372 (17.6%)
Deaths Reported
10,462
Hospitalizations
19,172
As Primary/Secondary Suspect
2,801
Life-Threatening
214
Disabilities

Active Ingredient: PIPERACILLIN SODIUM\TAZOBACTAM SODIUM ·

First Report: 18991231 · Latest Report: 20250915

What Are the Most Common PIPERACILLIN\TAZOBACTAM Side Effects?

#1 Most Reported
Drug ineffective
2,273 reports (11.9%)
#2 Most Reported
Off label use
1,586 reports (8.3%)
#3 Most Reported
Acute kidney injury
1,539 reports (8.0%)

All PIPERACILLIN\TAZOBACTAM Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Drug ineffective 2,273 11.9% 912 1,328
Off label use 1,586 8.3% 398 902
Acute kidney injury 1,539 8.0% 224 1,044
Drug reaction with eosinophilia and systemic symptoms 1,157 6.0% 81 762
Pyrexia 1,113 5.8% 180 795
Rash 962 5.0% 88 533
Condition aggravated 928 4.8% 280 534
Thrombocytopenia 694 3.6% 125 393
Diarrhoea 671 3.5% 142 514
Rash maculo-papular 629 3.3% 39 384
Dyspnoea 593 3.1% 183 376
Septic shock 561 2.9% 341 372
Pruritus 559 2.9% 39 257
Neutropenia 541 2.8% 61 369
Eosinophilia 530 2.8% 33 357
Toxic epidermal necrolysis 490 2.6% 250 293
Multiple organ dysfunction syndrome 453 2.4% 358 277
Hypotension 449 2.3% 110 301
Drug hypersensitivity 430 2.2% 6 171
Pneumonia 425 2.2% 130 312

Who Reports PIPERACILLIN\TAZOBACTAM Side Effects? Age & Gender Data

Gender: 41.3% female, 58.7% male. Average age: 56.9 years. Most reports from: FR. View detailed demographics →

Is PIPERACILLIN\TAZOBACTAM Getting Safer? Reports by Year

YearReportsDeathsHosp.
2000 7 2 5
2001 3 0 0
2005 5 0 4
2006 3 0 1
2007 11 2 7
2008 29 15 22
2009 17 8 12
2010 16 1 11
2011 64 5 32
2012 113 10 91
2013 135 40 90
2014 489 63 339
2015 601 119 363
2016 751 168 522
2017 780 97 485
2018 944 141 547
2019 985 114 543
2020 1,487 283 824
2021 1,124 105 574
2022 823 71 448
2023 924 94 521
2024 709 78 372
2025 370 45 198

View full timeline →

What Is PIPERACILLIN\TAZOBACTAM Used For?

IndicationReports
Product used for unknown indication 2,895
Pneumonia 1,494
Infection 1,333
Antibiotic therapy 1,128
Sepsis 807
Evidence based treatment 402
Covid-19 353
Septic shock 344
Pyrexia 319
Urinary tract infection 307

PIPERACILLIN\TAZOBACTAM vs Alternatives: Which Is Safer?

PIPERACILLIN\TAZOBACTAM vs PIRACETAM PIPERACILLIN\TAZOBACTAM vs PIRARUBICIN PIPERACILLIN\TAZOBACTAM vs PIRFENIDONE PIPERACILLIN\TAZOBACTAM vs PIRIBEDIL PIPERACILLIN\TAZOBACTAM vs PIRITRAMIDE PIPERACILLIN\TAZOBACTAM vs PIROXICAM PIPERACILLIN\TAZOBACTAM vs PIRTOBRUTINIB PIPERACILLIN\TAZOBACTAM vs PIT VIPER IMMUNE GLOBULIN ANTIVENIN PIPERACILLIN\TAZOBACTAM vs PITAVASTATIN PIPERACILLIN\TAZOBACTAM vs PITOLISANT

Official FDA Label for PIPERACILLIN\TAZOBACTAM

Official prescribing information from the FDA-approved drug label.