REBIF: 1,748 Adverse Event Reports & Safety Profile
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1,748
Total FAERS Reports
90 (5.1%)
Deaths Reported
553
Hospitalizations
1,748
As Primary/Secondary Suspect
30
Life-Threatening
49
Disabilities
First Report: 1997 · Latest Report: 20140617
What Are the Most Common REBIF Side Effects?
#1 Most Reported
Multiple sclerosis relapse
158 reports (9.0%)
#2 Most Reported
Injection site erythema
137 reports (7.8%)
#3 Most Reported
Influenza like illness
128 reports (7.3%)
All REBIF Side Effects by Frequency
| Side Effect | Reports | % of Total | Deaths | Hosp. |
|---|---|---|---|---|
| Multiple sclerosis relapse | 158 | 9.0% | 3 | 99 |
| Injection site erythema | 137 | 7.8% | 1 | 26 |
| Influenza like illness | 128 | 7.3% | 2 | 23 |
| Fatigue | 123 | 7.0% | 1 | 45 |
| Injection site pain | 105 | 6.0% | 1 | 22 |
| Headache | 96 | 5.5% | 2 | 26 |
| Injection site bruising | 74 | 4.2% | 0 | 16 |
| Pyrexia | 74 | 4.2% | 5 | 33 |
| Fall | 73 | 4.2% | 2 | 36 |
| Pneumonia | 69 | 4.0% | 12 | 42 |
| Urinary tract infection | 69 | 4.0% | 8 | 46 |
| Depression | 65 | 3.7% | 3 | 22 |
| Pain | 63 | 3.6% | 0 | 23 |
| Hypertension | 61 | 3.5% | 1 | 28 |
| Malaise | 61 | 3.5% | 2 | 30 |
| Asthenia | 52 | 3.0% | 0 | 21 |
| Gait disturbance | 50 | 2.9% | 2 | 19 |
| Nausea | 48 | 2.8% | 1 | 17 |
| Pain in extremity | 47 | 2.7% | 2 | 14 |
| Muscular weakness | 44 | 2.5% | 4 | 20 |
Who Reports REBIF Side Effects? Age & Gender Data
Average age: 46.1 years. Most reports from: US. View detailed demographics →
Is REBIF Getting Safer? Reports by Year
| Year | Reports | Deaths | Hosp. |
|---|---|---|---|
| 2001 | 1 | 0 | 0 |
| 2003 | 6 | 1 | 4 |
| 2004 | 4 | 0 | 0 |
| 2005 | 11 | 0 | 3 |
| 2006 | 13 | 2 | 5 |
| 2007 | 22 | 0 | 13 |
| 2008 | 31 | 2 | 15 |
| 2009 | 26 | 4 | 15 |
| 2010 | 47 | 2 | 23 |
| 2011 | 57 | 4 | 28 |
| 2012 | 126 | 4 | 51 |
| 2013 | 483 | 19 | 189 |
| 2014 | 333 | 17 | 115 |
What Is REBIF Used For?
| Indication | Reports |
|---|---|
| Multiple sclerosis | 989 |
| Product used for unknown indication | 516 |
| Relapsing-remitting multiple sclerosis | 207 |
| Secondary progressive multiple sclerosis | 16 |
REBIF vs Alternatives: Which Is Safer?
REBIF vs REBOXETINE
REBIF vs RECLAST
REBIF vs RECOMBINANT VARICELLA ZOSTER VIRUS GLYCOPROTEIN E
REBIF vs REGADENOSON
REBIF vs REGORAFENIB
REBIF vs REGORAFENIB\REGORAFENIB
REBIF vs RELATLIMAB
REBIF vs RELPAX
REBIF vs RELUGOLIX
REBIF vs REMDESIVIR
Official FDA Label for REBIF
Official prescribing information from the FDA-approved drug label.