SENNA LEAF: 932 Adverse Event Reports & Safety Profile
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Route: ORAL · Manufacturer: Boiron · HUMAN OTC DRUG · FDA Label: Available
First Report: 19950117 · Latest Report: 20250414
What Are the Most Common SENNA LEAF Side Effects?
All SENNA LEAF Side Effects by Frequency
| Side Effect | Reports | % of Total | Deaths | Hosp. |
|---|---|---|---|---|
| Asthma | 481 | 51.6% | 121 | 86 |
| Pain | 477 | 51.2% | 97 | 56 |
| Headache | 476 | 51.1% | 102 | 56 |
| Upper respiratory tract infection | 440 | 47.2% | 98 | 48 |
| Hepatic enzyme increased | 423 | 45.4% | 103 | 4 |
| Hyperhidrosis | 423 | 45.4% | 103 | 4 |
| Immunodeficiency | 420 | 45.1% | 102 | 4 |
| Hypersensitivity | 419 | 45.0% | 98 | 4 |
| Food allergy | 417 | 44.7% | 101 | 4 |
| Rash erythematous | 393 | 42.2% | 96 | 1 |
| Rheumatoid arthritis | 393 | 42.2% | 97 | 1 |
| Constipation | 392 | 42.1% | 100 | 65 |
| Fatigue | 384 | 41.2% | 101 | 52 |
| Off label use | 382 | 41.0% | 110 | 43 |
| Drug hypersensitivity | 364 | 39.1% | 96 | 47 |
| Exposure during pregnancy | 353 | 37.9% | 91 | 4 |
| Fluid retention | 344 | 36.9% | 102 | 4 |
| Temperature regulation disorder | 340 | 36.5% | 98 | 4 |
| Back pain | 332 | 35.6% | 95 | 14 |
| Bursitis | 323 | 34.7% | 99 | 1 |
Who Reports SENNA LEAF Side Effects? Age & Gender Data
Gender: 92.3% female, 7.7% male. Average age: 54.9 years. Most reports from: CA. View detailed demographics →
Is SENNA LEAF Getting Safer? Reports by Year
| Year | Reports | Deaths | Hosp. |
|---|---|---|---|
| 2010 | 1 | 0 | 1 |
| 2011 | 2 | 0 | 0 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 9 | 3 | 5 |
| 2015 | 19 | 1 | 15 |
| 2016 | 12 | 6 | 6 |
| 2017 | 13 | 0 | 8 |
| 2018 | 9 | 0 | 8 |
| 2019 | 10 | 0 | 6 |
| 2020 | 19 | 11 | 5 |
| 2021 | 9 | 0 | 5 |
| 2022 | 8 | 2 | 5 |
| 2023 | 5 | 2 | 2 |
| 2024 | 1 | 0 | 1 |
| 2025 | 4 | 0 | 1 |
What Is SENNA LEAF Used For?
| Indication | Reports |
|---|---|
| Product used for unknown indication | 794 |
| Constipation | 46 |
| Pain | 8 |
| Laxative supportive care | 6 |
| Weight decreased | 5 |
SENNA LEAF vs Alternatives: Which Is Safer?
Official FDA Label for SENNA LEAF
Official prescribing information from the FDA-approved drug label.
FDA Approved Uses (Indications)
Uses: See symptoms on front panel. Relieves ketone breath *
Dosage & Administration
Adults and children: At the onset of symptoms, dissolve 5 pellets under the tongue 3 times a day until symptoms are relieved or as directed by a doctor.
Active Ingredient
SENNA 200CK HPUS Less than 10 -12 mg athraquinone glycosides per pellet Active ingredient**: See product name on front panel (contains 0.443 mg of the active ingredient per pellet).
Inactive Ingredients
lactose, sucrose