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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

TIOPRONIN Drug Interactions: What You Need to Know

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Drug Interactions (FDA Label)

INTERACTIONS

7.1 Alcohol Tiopronin is released faster from tiopronin delayed-release tablets in the presence of alcohol and the risk for adverse events associated with tiopronin delayed-release tablets when taken with alcohol is unknown. Avoid alcohol consumption 2 hours before and 3 hours after taking tiopronin delayed-release tablets <span class="opacity-50 text-xs">[see Clinical Pharmacology ( 12.3 )]</span> .

Contraindications

THIOLA is contraindicated in patients with hypersensitivity to tiopronin or any other components of THIOLA [see Warnings and Precautions (5.2)]. ----------------------------------------------CONTRAINDICATIONS------------------------------------------

Related Warnings

AND PRECAUTIONS

5.1 Proteinuria Proteinuria, including nephrotic syndrome, and membranous nephropathy, have been reported with tiopronin use. Pediatric patients receiving greater than 50 mg/kg of tiopronin per day may be at increased risk for proteinuria <span class="opacity-50 text-xs">[see Dosage and Administration (2.3 ), Adverse Reactions (6.1, 6.2), Use in Specific Populations (8.4)]</span>. Monitor patients for the development of proteinuria and discontinue therapy in patients who develop proteinuria <span class="opacity-50 text-xs">[see Dosage and Administration (2.3)]</span>.

5.2 Hypersensitivity Reactions Hypersensitivity reactions (drug fever, rash, fever, arthralgia and lymphadenopathy) have been reported <span class="opacity-50 text-xs">[see Contraindications (4)]</span>. Proteinuria, including nephrotic syndrome, and membranous nephropathy, has been reported with tiopronin use. Pediatric patients receiving greater than 50 mg/kg of tiopronin per day may be at increased risk for proteinuria. (2.1, 5.1, 8.4) Hypersensitivity reactions have been reported during tiopronin treatment. (4, 5.2)

5.1 Proteinuria Proteinuria, including nephrotic syndrome, and membranous nephropathy, have been reported with tiopronin use. Pediatric patients receiving greater than 50 mg/kg of tiopronin per day may be at increased risk for proteinuria <span class="opacity-50 text-xs">[see Dosage and Administration (2.3), Adverse Reactions (6.1, 6.2), Use in Specific Populations (8.4)]</span>. Monitor patients for the development of proteinuria and discontinue therapy in patients who develop proteinuria <span class="opacity-50 text-xs">[see Dosage and Administration (2.3)]</span>.

5.2 Hypersensitivity Reactions Hypersensitivity reactions (drug fever, rash, fever, arthralgia and lymphadenopathy) have been reported <span class="opacity-50 text-xs">[see Contraindications (4)]</span>.

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