Does TOFACITINIB Cause Nephrolithiasis? 699 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 699 reports of Nephrolithiasis have been filed in association with TOFACITINIB (XELJANZ XR). This represents 0.5% of all adverse event reports for TOFACITINIB.
699
Reports of Nephrolithiasis with TOFACITINIB
0.5%
of all TOFACITINIB reports
8
Deaths
280
Hospitalizations
How Dangerous Is Nephrolithiasis From TOFACITINIB?
Of the 699 reports, 8 (1.1%) resulted in death, 280 (40.1%) required hospitalization, and 10 (1.4%) were considered life-threatening.
Is Nephrolithiasis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for TOFACITINIB. However, 699 reports have been filed with the FAERS database.
What Other Side Effects Does TOFACITINIB Cause?
Drug ineffective (30,382)
Pain (21,659)
Condition aggravated (16,925)
Arthralgia (15,640)
Fatigue (13,551)
Rheumatoid arthritis (12,277)
Off label use (11,736)
Headache (11,061)
Joint swelling (10,686)
Malaise (9,040)
What Other Drugs Cause Nephrolithiasis?
ADALIMUMAB (2,416)
ETANERCEPT (1,292)
INFLIXIMAB (981)
METHOTREXATE (979)
ABATACEPT (788)
TOPIRAMATE (768)
CERTOLIZUMAB PEGOL (735)
RITUXIMAB (709)
SODIUM OXYBATE (698)
PREDNISONE (694)
Which TOFACITINIB Alternatives Have Lower Nephrolithiasis Risk?
TOFACITINIB vs TOFERSEN
TOFACITINIB vs TOLNAFTATE
TOFACITINIB vs TOLODODEKIN ALFA
TOFACITINIB vs TOLTERODINE
TOFACITINIB vs TOLVAPTAN