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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

TRIMEPRAZINE: 3,601 Adverse Event Reports & Safety Profile

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3,601
Total FAERS Reports
548 (15.2%)
Deaths Reported
2,280
Hospitalizations
3,601
As Primary/Secondary Suspect
537
Life-Threatening
49
Disabilities
Approved Prior to Jan 1, 1982
FDA Approved
Discontinued
Status
Yes
Generic Available

FDA Application: 011316 ·

First Report: 19911214 · Latest Report: 20250630

What Are the Most Common TRIMEPRAZINE Side Effects?

#1 Most Reported
Intentional overdose
676 reports (18.8%)
#2 Most Reported
Coma
567 reports (15.7%)
#3 Most Reported
Intentional self-injury
508 reports (14.1%)

All TRIMEPRAZINE Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Intentional overdose 676 18.8% 8 644
Coma 567 15.8% 9 367
Intentional self-injury 508 14.1% 0 499
Toxicity to various agents 391 10.9% 110 237
Somnolence 332 9.2% 8 286
Poisoning deliberate 323 9.0% 23 217
Drug abuse 237 6.6% 108 56
Tachycardia 202 5.6% 9 170
Hypotension 181 5.0% 11 142
Suicide attempt 164 4.6% 1 149
Fatigue 162 4.5% 0 140
Depressed level of consciousness 157 4.4% 12 117
Electrocardiogram qt prolonged 136 3.8% 5 86
Pneumonia aspiration 111 3.1% 2 71
Rhabdomyolysis 109 3.0% 10 85
Cardio-respiratory arrest 108 3.0% 83 34
Poisoning 104 2.9% 49 32
Fall 101 2.8% 10 77
Off label use 101 2.8% 14 72
Death 100 2.8% 100 2

Who Reports TRIMEPRAZINE Side Effects? Age & Gender Data

Gender: 57.1% female, 42.9% male. Average age: 43.9 years. Most reports from: FR. View detailed demographics →

Is TRIMEPRAZINE Getting Safer? Reports by Year

YearReportsDeathsHosp.
2004 1 1 0
2008 1 0 0
2009 3 0 2
2010 9 1 7
2011 7 1 2
2012 20 2 14
2013 22 6 17
2014 90 1 69
2015 110 20 83
2016 144 23 111
2017 247 48 161
2018 521 29 407
2019 547 67 438
2020 326 41 202
2021 272 24 160
2022 186 51 97
2023 274 11 159
2024 253 29 146
2025 100 4 65

View full timeline →

What Is TRIMEPRAZINE Used For?

IndicationReports
Product used for unknown indication 1,755
Insomnia 269
Bipolar disorder 142
Depression 96
Psychotic disorder 93
Toxicity to various agents 85
Intentional overdose 80
Sleep disorder 75
Poisoning deliberate 70
Suicide attempt 69

TRIMEPRAZINE vs Alternatives: Which Is Safer?

TRIMEPRAZINE vs TRIMETAZIDINE TRIMEPRAZINE vs TRIMETHOBENZAMIDE TRIMEPRAZINE vs TRIMETHOPRIM TRIMEPRAZINE vs TRIMIPRAMINE TRIMEPRAZINE vs TRIPROLIDINE TRIMEPRAZINE vs TRIPTORELIN TRIMEPRAZINE vs TRISODIUM TRIMEPRAZINE vs TROFINETIDE TRIMEPRAZINE vs TROFOSFAMIDE TRIMEPRAZINE vs TROPATEPINE

Official FDA Label for TRIMEPRAZINE

Official prescribing information from the FDA-approved drug label.