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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

TRIMETAZIDINE: 431 Adverse Event Reports & Safety Profile

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431
Total FAERS Reports
33 (7.7%)
Deaths Reported
264
Hospitalizations
431
As Primary/Secondary Suspect
13
Life-Threatening
11
Disabilities

Active Ingredient: TRIMETAZIDINE DIHYDROCHLORIDE ·

First Report: 2000 · Latest Report: 20250310

What Are the Most Common TRIMETAZIDINE Side Effects?

#1 Most Reported
Cardiac failure
73 reports (16.9%)
#2 Most Reported
Rales
63 reports (14.6%)
#3 Most Reported
Ejection fraction decreased
62 reports (14.4%)

All TRIMETAZIDINE Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Cardiac failure 73 16.9% 2 69
Rales 63 14.6% 0 63
Ejection fraction decreased 62 14.4% 0 62
Dyspnoea 59 13.7% 0 52
Fatigue 59 13.7% 0 51
Diastolic dysfunction 52 12.1% 0 43
Oedema peripheral 49 11.4% 0 46
Tricuspid valve incompetence 49 11.4% 0 49
Mitral valve incompetence 45 10.4% 0 44
Dyspnoea at rest 44 10.2% 0 44
Left ventricular dysfunction 43 10.0% 0 42
Hypertension 42 9.7% 2 33
Hypotension 42 9.7% 0 34
Cardiomegaly 40 9.3% 0 39
Atrial fibrillation 37 8.6% 0 31
Acute myocardial infarction 36 8.4% 0 36
Left ventricular hypertrophy 36 8.4% 0 27
Stenosis 36 8.4% 0 36
Asthenia 35 8.1% 0 31
Bundle branch block left 34 7.9% 0 34

Who Reports TRIMETAZIDINE Side Effects? Age & Gender Data

Gender: 32.3% female, 67.7% male. Average age: 68.4 years. Most reports from: PL. View detailed demographics →

Is TRIMETAZIDINE Getting Safer? Reports by Year

YearReportsDeathsHosp.
2000 6 0 6
2005 8 0 8
2007 1 0 1
2008 6 0 6
2009 13 9 4
2012 10 0 9
2013 6 0 4
2014 9 0 3
2015 21 1 14
2016 30 8 17
2017 28 0 25
2018 23 2 10
2019 49 0 37
2020 18 0 12
2021 25 0 16
2022 9 2 6
2023 8 0 3
2024 6 0 0
2025 2 0 0

View full timeline →

What Is TRIMETAZIDINE Used For?

IndicationReports
Product used for unknown indication 266
Hypertension 20
Angina pectoris 17
Coronary artery disease 11
Cardiac disorder 7
Vertigo 7
Myocardial ischaemia 6
Myocardial infarction 5

TRIMETAZIDINE vs Alternatives: Which Is Safer?

TRIMETAZIDINE vs TRIMETHOBENZAMIDE TRIMETAZIDINE vs TRIMETHOPRIM TRIMETAZIDINE vs TRIMIPRAMINE TRIMETAZIDINE vs TRIPROLIDINE TRIMETAZIDINE vs TRIPTORELIN TRIMETAZIDINE vs TRISODIUM TRIMETAZIDINE vs TROFINETIDE TRIMETAZIDINE vs TROFOSFAMIDE TRIMETAZIDINE vs TROPATEPINE TRIMETAZIDINE vs TROPICAMIDE

Official FDA Label for TRIMETAZIDINE

Official prescribing information from the FDA-approved drug label.