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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

ZIV-AFLIBERCEPT: 1,039 Adverse Event Reports & Safety Profile

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1,039
Total FAERS Reports
167 (16.1%)
Deaths Reported
501
Hospitalizations
1,039
As Primary/Secondary Suspect
53
Life-Threatening
16
Disabilities
Prescription
Status

FDA Application: 125418 ·

First Report: 20130606 · Latest Report: 20250829

What Are the Most Common ZIV-AFLIBERCEPT Side Effects?

#1 Most Reported
Diarrhoea
150 reports (14.4%)
#2 Most Reported
Hypertension
115 reports (11.1%)
#3 Most Reported
Neutropenia
92 reports (8.9%)

All ZIV-AFLIBERCEPT Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Diarrhoea 150 14.4% 17 90
Hypertension 115 11.1% 1 44
Neutropenia 92 8.9% 5 43
Asthenia 62 6.0% 2 39
Vomiting 56 5.4% 9 37
Proteinuria 54 5.2% 0 23
Nausea 48 4.6% 6 24
Death 45 4.3% 44 5
Fatigue 39 3.8% 5 26
Neuropathy peripheral 38 3.7% 0 21
Decreased appetite 37 3.6% 3 28
Pyrexia 37 3.6% 4 28
Stomatitis 37 3.6% 5 26
Febrile neutropenia 35 3.4% 15 27
Abdominal pain 33 3.2% 6 23
Disease progression 29 2.8% 12 11
Neutrophil count decreased 29 2.8% 4 13
Alopecia 28 2.7% 1 19
Anaemia 27 2.6% 5 16
Dyspnoea 27 2.6% 5 22

Who Reports ZIV-AFLIBERCEPT Side Effects? Age & Gender Data

Gender: 38.5% female, 61.5% male. Average age: 64.5 years. Most reports from: JP. View detailed demographics →

Is ZIV-AFLIBERCEPT Getting Safer? Reports by Year

YearReportsDeathsHosp.
2013 6 3 2
2014 52 11 29
2015 146 12 92
2016 115 19 66
2017 114 9 77
2018 111 18 50
2019 77 23 39
2020 35 6 17
2021 20 0 10
2022 33 2 15
2023 34 15 14
2024 17 0 6
2025 2 0 0

View full timeline →

What Is ZIV-AFLIBERCEPT Used For?

IndicationReports
Colorectal cancer metastatic 241
Colon cancer 179
Product used for unknown indication 101
Rectal cancer 92
Adenocarcinoma of colon 71
Colorectal cancer 71
Colon cancer metastatic 53
Rectal adenocarcinoma 35
Metastases to lung 17
Rectal cancer metastatic 15

ZIV-AFLIBERCEPT vs Alternatives: Which Is Safer?

ZIV-AFLIBERCEPT vs ZOCOR ZIV-AFLIBERCEPT vs ZOFENOPRIL ZIV-AFLIBERCEPT vs ZOFRAN ZIV-AFLIBERCEPT vs ZOLADEX ZIV-AFLIBERCEPT vs ZOLBETUXIMAB ZIV-AFLIBERCEPT vs ZOLBETUXIMAB-CLZB ZIV-AFLIBERCEPT vs ZOLEDRONIC ACID ZIV-AFLIBERCEPT vs ZOLMITRIPTAN ZIV-AFLIBERCEPT vs ZOLOFT ZIV-AFLIBERCEPT vs ZOLPIDEM

Official FDA Label for ZIV-AFLIBERCEPT

Official prescribing information from the FDA-approved drug label.