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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Antidepressant therapy: Which Medications Are Safest? (158 Drugs Compared)

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158 medications are used for Antidepressant therapy, with 3,497 combined adverse event reports. The most reported drugs for Antidepressant therapy are CITALOPRAM and SERTRALINE.

3,497
Total Reports
158
Drugs Used

All Medications for Antidepressant therapy Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
CITALOPRAM Citalopram 676 1,947 1,002 46.7%
SERTRALINE Sertraline Hydrochloride 480 6,889 19,327 11.5%
VENLAFAXINE Venlafaxine Hydrochloride 441 7,521 15,749 15.7%
MIRTAZAPINE Mirtazapine 318 5,410 11,495 18.9%
FLUOXETINE Fluoxetine 267 5,534 11,247 17.7%
CITALOPRAM HYDROBROMIDE Citalopram Hydrobromide 259 6,745 9,074 24.9%
DULOXETINE Duloxetine Hydrochloride 253 4,044 10,622 7.7%
BUPROPION Bupropion Hydrochloride (XL) 252 8,577 10,246 24.1%
ESCITALOPRAM OXALATE Escitalopram 239 3,531 11,942 11.6%
PAROXETINE Paroxetine 220 2,854 8,171 13.3%
TRAZODONE Trazodone Hydrochloride 209 6,213 7,153 32.4%
AMITRIPTYLINE AMITRIPTYLINE HYDROCHLORIDE 112 4,837 7,290 23.7%
QUETIAPINE Quetiapine 89 13,610 31,386 18.6%
ARIPIPRAZOLE Aripiprazole 65 3,863 20,713 5.8%
CLOMIPRAMINE Clomipramine Hydrochloride 53 497 1,967 13.0%
DESVENLAFAXINE Desvenlafaxine Succinate 52 447 1,093 5.0%
LAMOTRIGINE Lamotrigine ER 46 6,604 17,639 13.7%
OLANZAPINE Olanzapine 40 5,535 21,934 10.8%
VORTIOXETINE HYDROBROMIDE Trintellix 39 400 1,741 2.9%
DOXEPIN doxepin hydrochloride 37 1,613 1,091 40.1%

View all 158 drugs →

Most Reported Drugs for Antidepressant therapy

#1 most reported
#2 most reported
#3 most reported