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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Drug withdrawal syndrome: Which Medications Are Safest? (120 Drugs Compared)

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120 medications are used for Drug withdrawal syndrome, with 949 combined adverse event reports. The most reported drugs for Drug withdrawal syndrome are BUPRENORPHINE\NALOXONE and BUPRENORPHINE.

949
Total Reports
120
Drugs Used

All Medications for Drug withdrawal syndrome Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
BUPRENORPHINE\NALOXONE - 219 1,119 2,872 5.2%
BUPRENORPHINE Buprenorphine and Naloxone 132 25,813 9,467 31.5%
LOPERAMIDE Anti-diarrheal 128 1,551 4,298 8.6%
CLONIDINE Clonidine hydrochloride 70 2,401 3,920 19.1%
METHADONE METHADONE HYDROCHLORIDE 67 10,719 5,514 40.8%
DIAZEPAM Diazepam 63 12,045 13,635 31.6%
BACLOFEN BACLOFEN 35 2,958 8,773 11.5%
LORAZEPAM Lorazepam 35 6,187 15,431 18.5%
HYDROMORPHONE Hydromorphone Hydrochloride 33 28,491 10,395 34.1%
PREGABALIN Pregabalin 30 8,959 22,920 8.8%
QUETIAPINE Quetiapine 30 13,610 31,386 18.6%
GABAPENTIN Gabapentin 24 11,101 16,499 14.9%
LOFEXIDINE Lofexidine hydrochloride 24 0 17 N/A
FENTANYL FENTANYL 17 42,491 15,153 45.0%
MORPHINE Morphine Sulfate 17 38,212 17,386 31.7%
MIDAZOLAM Midazolam 16 1,808 4,691 16.2%
OXYCODONE Oxycodone Hydrochloride 16 55,140 21,279 28.9%
CLONAZEPAM Clonazepam 15 8,488 12,506 21.5%
PHENOBARBITAL Phenobarbital Sodium 15 945 2,668 14.6%
HALOPERIDOL Haloperidol 14 1,882 7,393 11.8%

View all 120 drugs →

Most Reported Drugs for Drug withdrawal syndrome

#1 most reported
#2 most reported
#3 most reported