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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Fatigue: Which Medications Are Safest? (405 Drugs Compared)

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405 medications are used for Fatigue, with 2,669 combined adverse event reports. The most reported drugs for Fatigue are MODAFINIL and TESTOSTERONE.

2,669
Total Reports
405
Drugs Used

All Medications for Fatigue Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
MODAFINIL Modafinil 222 157 556 4.7%
TESTOSTERONE Testosterone 203 1,091 5,432 4.0%
TESTOSTERONE CYPIONATE Testosterone Cypionate 181 230 1,826 4.4%
METHYLPHENIDATE Methylphenidate Hydrochloride 124 1,163 4,620 3.8%
ARMODAFINIL Armodafinil 108 27 240 1.1%
AMPHETAMINE ASPARTATE\AMPHETAMINE\DEXTROAMPHETAMINE SACCHARATE\DEXTROAMPHETAMINE - 102 688 767 4.3%
CEFUROXIME AXETIL Cefuroxime axetil 98 144 755 5.0%
ACETAMINOPHEN Hydrocodone Bitartrate and Acetaminophen 86 30,085 50,046 22.0%
DALFAMPRIDINE Dalfampridine 83 1,482 7,813 2.6%
AMANTADINE Amantadine 78 483 1,579 9.4%
IBUPROFEN equate ibuprofen 66 6,705 29,386 7.7%
BUPROPION Bupropion Hydrochloride (XL) 63 8,577 10,246 24.1%
PREGABALIN Pregabalin 51 8,959 22,920 8.8%
LISDEXAMFETAMINE DIMESYLATE LISDEXAMFETAMINE DIMESYLATE 48 122 2,028 0.7%
DULOXETINE Duloxetine Hydrochloride 42 4,044 10,622 7.7%
VENLAFAXINE Venlafaxine Hydrochloride 38 7,521 15,749 15.7%
SERTRALINE Sertraline Hydrochloride 35 6,889 19,327 11.5%
SODIUM OXYBATE sodium oxybate 27 537 6,147 0.9%
DEXAMETHASONE Dexamethasone Sodium Phosphate 23 22,319 51,311 17.8%
NUVIGIL - 23 1 13 0.4%

View all 405 drugs →

Most Reported Drugs for Fatigue

#1 most reported
#2 most reported
#3 most reported