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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Headache: Which Medications Are Safest? (852 Drugs Compared)

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852 medications are used for Headache, with 25,173 combined adverse event reports. The most reported drugs for Headache are ACETAMINOPHEN and IBUPROFEN.

25,173
Total Reports
852
Drugs Used

All Medications for Headache Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
ACETAMINOPHEN Hydrocodone Bitartrate and Acetaminophen 5,030 30,085 50,046 22.0%
IBUPROFEN equate ibuprofen 4,475 6,705 29,386 7.7%
ACETAMINOPHEN\ASPIRIN\CAFFEINE - 3,265 155 438 1.3%
NAPROXEN Naproxen Sodium 1,037 5,127 12,849 9.7%
SUMATRIPTAN sumatriptan succinate 1,020 305 1,580 1.7%
ERENUMAB-AOOE - 902 1,935 3,054 3.9%
TOPIRAMATE Topiramate 709 3,527 7,098 12.3%
RIMEGEPANT NURTEC ODT 629 77 217 0.8%
ACETAMINOPHEN\IBUPROFEN - 560 21 59 0.7%
DICLOFENAC Diclofenac Sodium Delayed Release 424 6,378 16,398 7.3%
GABAPENTIN Gabapentin 330 11,101 16,499 14.9%
DIPHENHYDRAMINE\IBUPROFEN - 323 111 118 2.8%
ONABOTULINUMTOXINA - 308 1,489 2,307 3.0%
TRAMADOL ConZip 308 14,555 19,235 19.2%
ASPIRIN Aspirin 299 13,029 53,089 14.1%
GALCANEZUMAB-GNLM - 293 66 681 0.2%
PREGABALIN Pregabalin 289 8,959 22,920 8.8%
ELETRIPTAN HYDROBROMIDE Eletriptan hydrobromide 277 12 271 0.6%
AMITRIPTYLINE AMITRIPTYLINE HYDROCHLORIDE 220 4,837 7,290 23.7%
OXYCODONE Oxycodone Hydrochloride 182 55,140 21,279 28.9%

View all 852 drugs →

Most Reported Drugs for Headache

#1 most reported
#2 most reported