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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Initial insomnia: Which Medications Are Safest? (63 Drugs Compared)

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63 medications are used for Initial insomnia, with 395 combined adverse event reports. The most reported drugs for Initial insomnia are ZOLPIDEM and DOXYLAMINE.

395
Total Reports
63
Drugs Used

All Medications for Initial insomnia Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
ZOLPIDEM Zolpidem Tartrate 56 3,908 7,033 18.2%
DOXYLAMINE CareOne Nighttime Sleep Aid 42 1,161 619 26.4%
RAMELTEON Ramelteon 41 61 182 7.3%
DIPHENHYDRAMINE\IBUPROFEN - 24 111 118 2.8%
SUVOREXANT BELSOMRA 22 219 572 2.3%
OXAZEPAM Oxazepam 17 2,965 6,242 23.8%
ESZOPICLONE Eszopiclone 14 447 448 18.3%
QUETIAPINE Quetiapine 14 13,610 31,386 18.6%
TRIMEPRAZINE - 13 548 2,280 15.2%
OLANZAPINE Olanzapine 12 5,535 21,934 10.8%
MELATONIN Melatonin 1527 10 812 2,253 19.8%
ZOPICLONE - 10 2,624 7,438 18.5%
ACETAMINOPHEN\DIPHENHYDRAMINE - 7 755 723 44.5%
DIAZEPAM Diazepam 7 12,045 13,635 31.6%
TRAZODONE Trazodone Hydrochloride 7 6,213 7,153 32.4%
DIPHENHYDRAMINE Allergy Relief 6 10,508 6,849 40.7%
GABAPENTIN Gabapentin 6 11,101 16,499 14.9%
HYDROXYZINE Hydroxyzine Hydrochloride 6 3,894 4,772 32.5%
MIANSERIN - 6 488 1,473 19.1%
SERTRALINE Sertraline Hydrochloride 6 6,889 19,327 11.5%

View all 63 drugs →

Most Reported Drugs for Initial insomnia

#1 most reported
#2 most reported
#3 most reported