Skip to content
Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Insomnia: Which Medications Are Safest? (630 Drugs Compared)

Wake Up Pain-Free — Sleep Like Never Before

Derila Ergo Pillow: ergonomic design, cooling tech. 75% OFF today.

Shop Now — 75% Off

630 medications are used for Insomnia, with 32,060 combined adverse event reports. The most reported drugs for Insomnia are SUVOREXANT and ZOLPIDEM.

32,060
Total Reports
630
Drugs Used

All Medications for Insomnia Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
SUVOREXANT BELSOMRA 6,209 219 572 2.3%
ZOLPIDEM Zolpidem Tartrate 3,623 3,908 7,033 18.2%
ZOPICLONE - 1,968 2,624 7,438 18.5%
DARIDOREXANT - 1,685 38 77 1.9%
QUETIAPINE Quetiapine 1,559 13,610 31,386 18.6%
TRAZODONE Trazodone Hydrochloride 1,527 6,213 7,153 32.4%
SODIUM OXYBATE sodium oxybate 1,334 537 6,147 0.9%
DOXYLAMINE CareOne Nighttime Sleep Aid 1,056 1,161 619 26.4%
ZOLPIDEM\ZOLPIDEM - 1,017 1,996 2,369 33.9%
CLONAZEPAM Clonazepam 1,003 8,488 12,506 21.5%
LORAZEPAM Lorazepam 886 6,187 15,431 18.5%
MIRTAZAPINE Mirtazapine 802 5,410 11,495 18.9%
ALPRAZOLAM Alprazolam 732 16,072 15,996 33.2%
DIPHENHYDRAMINE\IBUPROFEN - 716 111 118 2.8%
ESZOPICLONE Eszopiclone 692 447 448 18.3%
AMITRIPTYLINE AMITRIPTYLINE HYDROCHLORIDE 614 4,837 7,290 23.7%
LEMBOREXANT DAYVIGO 557 44 278 4.4%
OXAZEPAM Oxazepam 533 2,965 6,242 23.8%
TEMAZEPAM Temazepam 457 2,592 1,162 45.0%
DIAZEPAM Diazepam 395 12,045 13,635 31.6%

View all 630 drugs →

Most Reported Drugs for Insomnia

#1 most reported
#2 most reported
#3 most reported