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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Lyme disease: Which Medications Are Safest? (203 Drugs Compared)

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203 medications are used for Lyme disease, with 1,303 combined adverse event reports. The most reported drugs for Lyme disease are DOXYCYCLINE and DOXYCYCLINE HYCLATE.

1,303
Total Reports
203
Drugs Used

All Medications for Lyme disease Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
DOXYCYCLINE Doxycycline 386 1,653 5,618 9.3%
DOXYCYCLINE HYCLATE Doxycycline Hyclate 128 1,164 1,650 19.1%
CEFTRIAXONE Ceftriaxone 113 2,926 9,596 15.1%
DISULFIRAM Disulfiram 90 51 381 6.7%
AMOXICILLIN Amoxicillin and Clavulanate Potassium 45 1,212 11,721 4.0%
SULFAMETHOXAZOLE\TRIMETHOPRIM - 34 5,777 19,426 14.9%
AZITHROMYCIN AZITHROMYCIN 33 1,405 5,983 8.0%
ATOVAQUONE Atovaquone 28 366 1,110 16.1%
AZITHROMYCIN ANHYDROUS - 28 1,333 4,313 9.2%
PREGABALIN Pregabalin 27 8,959 22,920 8.8%
CEFUROXIME AXETIL Cefuroxime axetil 23 144 755 5.0%
MINOCYCLINE Minocycline Hydrochloride 23 1,530 2,364 23.2%
CIPROFLOXACIN Ciprofloxacin 21 2,671 13,894 6.1%
PENICILLIN G BENZATHINE Lentocilin 21 37 175 3.3%
HUMAN IMMUNOGLOBULIN G BIVIGAM 19 5,286 16,081 7.5%
DOXYCYCLINE\DOXYCYCLINE HYCLATE - 18 213 433 20.6%
HYDROXYCHLOROQUINE HYDROXYCHLOROQUINE SULFATE 18 6,506 16,905 9.8%
NITAZOXANIDE Nitazoxanide 18 26 42 5.7%
RIFAMPIN Rifampin 16 1,439 5,764 10.8%
CLARITHROMYCIN Clarithromycin 15 987 6,385 5.2%

View all 203 drugs →

Most Reported Drugs for Lyme disease

#1 most reported
#2 most reported
#3 most reported