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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Migraine prophylaxis: Which Medications Are Safest? (166 Drugs Compared)

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166 medications are used for Migraine prophylaxis, with 13,969 combined adverse event reports. The most reported drugs for Migraine prophylaxis are ERENUMAB-AOOE and TOPIRAMATE.

13,969
Total Reports
166
Drugs Used

All Medications for Migraine prophylaxis Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
ERENUMAB-AOOE - 9,326 1,935 3,054 3.9%
TOPIRAMATE Topiramate 1,227 3,527 7,098 12.3%
GALCANEZUMAB-GNLM - 1,066 66 681 0.2%
RIMEGEPANT NURTEC ODT 524 77 217 0.8%
FREMANEZUMAB-VFRM - 461 74 558 0.8%
EPTINEZUMAB-JJMR - 263 42 438 0.6%
PROPRANOLOL Propranolol Hydrochloride 194 3,221 4,912 16.6%
AMITRIPTYLINE AMITRIPTYLINE HYDROCHLORIDE 185 4,837 7,290 23.7%
ATOGEPANT Qulipta 177 46 277 1.0%
ONABOTULINUMTOXINA - 159 1,489 2,307 3.0%
VENLAFAXINE Venlafaxine Hydrochloride 98 7,521 15,749 15.7%
CANDESARTAN - 94 1,899 5,063 21.0%
METOPROLOL metoprolol succinate 85 6,575 15,925 15.9%
MAGNESIUM citroma 68 1,878 4,530 19.3%
RIBOFLAVIN - 64 407 570 47.9%
GABAPENTIN Gabapentin 62 11,101 16,499 14.9%
VALPROIC ACID Valproic Acid 62 2,667 8,183 13.3%
PREGABALIN Pregabalin 54 8,959 22,920 8.8%
VERAPAMIL Verapamil Hydrochloride 51 2,630 3,576 28.2%
ERENUMAB AIMOVIG 48 363 498 30.7%

View all 166 drugs →

Most Reported Drugs for Migraine prophylaxis

#1 most reported
#2 most reported
#3 most reported