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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Obesity: Which Medications Are Safest? (217 Drugs Compared)

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217 medications are used for Obesity, with 6,217 combined adverse event reports. The most reported drugs for Obesity are SEMAGLUTIDE and LIRAGLUTIDE.

6,217
Total Reports
217
Drugs Used

All Medications for Obesity Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
SEMAGLUTIDE WEGOVY 2,586 792 11,258 1.3%
LIRAGLUTIDE Victoza 1,090 994 4,819 4.3%
BUPROPION\NALTREXONE - 726 30 628 0.4%
TIRZEPATIDE Zepbound 700 455 5,527 0.5%
ORLISTAT Xenical 163 31 329 0.5%
PHENTERMINE Phentermine Hydrochloride 127 222 399 12.5%
DULAGLUTIDE Trulicity 109 1,054 6,536 1.4%
METFORMIN Metformin Hydrochloride 100 11,550 40,702 12.7%
PHENTERMINE\TOPIRAMATE - 86 9 170 0.2%
TOPIRAMATE Topiramate 86 3,527 7,098 12.3%
LORCASERIN - 79 15 187 0.6%
AMBRISENTAN AMBRISENTAN 60 10,291 32,910 11.9%
EXENATIDE Exenatide 30 1,228 2,512 3.9%
ATORVASTATIN Atorvastatin calcium 26 4,992 24,078 6.3%
DEXTROAMPHETAMINE Zenzedi 22 133 315 6.2%
FLUOXETINE Fluoxetine 20 5,534 11,247 17.7%
LIOTHYRONINE Liothyronine Sodium 20 41 501 1.5%
BELVIQ - 19 1 7 0.3%
HYDROCHLOROTHIAZIDE Irbesartan and Hydrochlorothiazide 18 2,177 10,714 10.4%
OXAZOLAM - 18 1 17 4.2%

View all 217 drugs →

Most Reported Drugs for Obesity

#1 most reported
#2 most reported
#3 most reported