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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Off label use: Which Medications Are Safest? (1,336 Drugs Compared)

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1,336 medications are used for Off label use, with 42,134 combined adverse event reports. The most reported drugs for Off label use are LENALIDOMIDE and ECULIZUMAB.

42,134
Total Reports
1,336
Drugs Used

All Medications for Off label use Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
LENALIDOMIDE LENALIDOMIDE 5,767 35,942 86,495 10.3%
ECULIZUMAB SOLIRIS 3,550 4,626 12,421 10.5%
CERTOLIZUMAB PEGOL Cimzia 2,256 5,361 17,641 5.4%
ABOBOTULINUMTOXINA - 2,170 109 406 1.9%
LEVETIRACETAM Levetiracetam 2,161 4,322 19,165 6.9%
APREMILAST Otezla 1,995 4,704 9,544 3.4%
PROPRANOLOL Propranolol Hydrochloride 1,576 3,221 4,912 16.6%
CETIRIZINE Cetirizine 1,416 4,787 8,423 10.0%
HUMAN IMMUNOGLOBULIN G BIVIGAM 1,129 5,286 16,081 7.5%
THALIDOMIDE Thalomid 1,033 3,085 4,632 17.7%
LACOSAMIDE Lacosamide 842 1,987 6,845 9.4%
RITUXIMAB Rituxan 674 28,910 54,631 16.2%
LIDOCAINE Burn Relief 660 1,738 5,570 7.6%
CETIRIZINE\PSEUDOEPHEDRINE - 531 2,361 2,599 37.5%
ETANERCEPT ENBREL 507 10,338 36,932 2.9%
IRINOTECAN Irinotecan Hydrochloride 444 4,530 10,384 16.2%
POMALIDOMIDE Pomalyst 434 12,672 24,801 13.7%
LANREOTIDE Lanreotide Acetate 429 1,434 2,178 15.9%
BEVACIZUMAB JOBEVNE 413 17,498 23,114 22.4%
TOBRAMYCIN TOBRAMYCIN 386 1,306 5,106 11.3%

View all 1,336 drugs →

Most Reported Drugs for Off label use

#1 most reported
#2 most reported
#3 most reported