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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Overweight: Which Medications Are Safest? (74 Drugs Compared)

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74 medications are used for Overweight, with 1,837 combined adverse event reports. The most reported drugs for Overweight are BUPROPION\NALTREXONE and SEMAGLUTIDE.

1,837
Total Reports
74
Drugs Used

All Medications for Overweight Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
BUPROPION\NALTREXONE - 803 30 628 0.4%
SEMAGLUTIDE WEGOVY 497 792 11,258 1.3%
LIRAGLUTIDE Victoza 193 994 4,819 4.3%
TIRZEPATIDE Zepbound 83 455 5,527 0.5%
ORLISTAT Xenical 51 31 329 0.5%
PHENTERMINE Phentermine Hydrochloride 27 222 399 12.5%
METFORMIN Metformin Hydrochloride 24 11,550 40,702 12.7%
DULAGLUTIDE Trulicity 21 1,054 6,536 1.4%
ATORVASTATIN Atorvastatin calcium 19 4,992 24,078 6.3%
EXENATIDE Exenatide 13 1,228 2,512 3.9%
TOPIRAMATE Topiramate 10 3,527 7,098 12.3%
BUPROPION Bupropion Hydrochloride (XL) 8 8,577 10,246 24.1%
LORCASERIN - 8 15 187 0.6%
BENFLUOREX - 7 8 25 16.0%
PHENDIMETRAZINE Phendimetrazine Tartrate 7 41 18 43.2%
ALBIGLUTIDE - 5 33 323 0.4%
DAPAGLIFLOZIN PROPANEDIOL FARXIGA 5 3,694 2,425 21.9%
PHENTERMINE\TOPIRAMATE - 5 9 170 0.2%
PHENYLPROPANOLAMINE - 5 93 29 66.0%

View all 74 drugs →

Most Reported Drugs for Overweight

#1 most reported
#2 most reported
#3 most reported