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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Pain: Which Medications Are Safest? (1,749 Drugs Compared)

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1,749 medications are used for Pain, with 149,263 combined adverse event reports. The most reported drugs for Pain are OXYCODONE and FENTANYL.

149,263
Total Reports
1,749
Drugs Used

All Medications for Pain Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
OXYCODONE Oxycodone Hydrochloride 39,706 55,140 21,279 28.9%
FENTANYL FENTANYL 31,689 42,491 15,153 45.0%
MORPHINE Morphine Sulfate 30,900 38,212 17,386 31.7%
BUPRENORPHINE Buprenorphine and Naloxone 28,541 25,813 9,467 31.5%
ACETAMINOPHEN\OXYCODONE - 27,508 31,342 7,703 31.5%
HYDROMORPHONE Hydromorphone Hydrochloride 27,027 28,491 10,395 34.1%
ACETAMINOPHEN\HYDROCODONE - 26,494 31,727 6,901 29.1%
HYDROCODONE Hydrocodone Bitartrate 23,966 24,200 3,569 50.6%
TAPENTADOL Nucynta 22,976 20,205 3,304 69.2%
OXYMORPHONE Oxymorphone Hydrochloride 22,873 22,403 2,692 58.8%
ASPIRIN\OXYCODONE - 22,295 20,381 2,103 79.1%
ACETAMINOPHEN Hydrocodone Bitartrate and Acetaminophen 14,553 30,085 50,046 22.0%
TRAMADOL ConZip 9,194 14,555 19,235 19.2%
IBUPROFEN equate ibuprofen 8,142 6,705 29,386 7.7%
PREGABALIN Pregabalin 7,844 8,959 22,920 8.8%
NAPROXEN Naproxen Sodium 7,447 5,127 12,849 9.7%
DICLOFENAC Diclofenac Sodium Delayed Release 5,960 6,378 16,398 7.3%
GABAPENTIN Gabapentin 4,501 11,101 16,499 14.9%
DULOXETINE Duloxetine Hydrochloride 3,418 4,044 10,622 7.7%
LIDOCAINE Burn Relief 2,110 1,738 5,570 7.6%

View all 1,749 drugs →

Most Reported Drugs for Pain

#1 most reported
#2 most reported
#3 most reported