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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Pain management: Which Medications Are Safest? (283 Drugs Compared)

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283 medications are used for Pain management, with 4,823 combined adverse event reports. The most reported drugs for Pain management are OXYCODONE and MORPHINE.

4,823
Total Reports
283
Drugs Used

All Medications for Pain management Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
OXYCODONE Oxycodone Hydrochloride 1,049 55,140 21,279 28.9%
MORPHINE Morphine Sulfate 537 38,212 17,386 31.7%
ACETAMINOPHEN Hydrocodone Bitartrate and Acetaminophen 533 30,085 50,046 22.0%
FENTANYL FENTANYL 533 42,491 15,153 45.0%
HYDROMORPHONE Hydromorphone Hydrochloride 463 28,491 10,395 34.1%
BUPRENORPHINE Buprenorphine and Naloxone 457 25,813 9,467 31.5%
ACETAMINOPHEN\HYDROCODONE - 360 31,727 6,901 29.1%
ACETAMINOPHEN\OXYCODONE - 353 31,342 7,703 31.5%
TRAMADOL ConZip 302 14,555 19,235 19.2%
GABAPENTIN Gabapentin 277 11,101 16,499 14.9%
CELECOXIB Celecoxib 185 4,470 9,081 14.1%
IBUPROFEN equate ibuprofen 171 6,705 29,386 7.7%
BUPRENORPHINE\NALOXONE - 159 1,119 2,872 5.2%
PREGABALIN Pregabalin 145 8,959 22,920 8.8%
HYDROCODONE Hydrocodone Bitartrate 121 24,200 3,569 50.6%
LIDOCAINE Burn Relief 111 1,738 5,570 7.6%
LORAZEPAM Lorazepam 108 6,187 15,431 18.5%
METHADONE METHADONE HYDROCHLORIDE 106 10,719 5,514 40.8%
BUPIVACAINE Bupivacaine Hydrochloride 92 466 2,367 4.1%
ACETAMINOPHEN\OXYCODONE\OXYCODONE TEREPHTHALATE - 75 1,069 809 9.1%

View all 283 drugs →

Most Reported Drugs for Pain management

#1 most reported
#2 most reported
#3 most reported