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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Pain prophylaxis: Which Medications Are Safest? (88 Drugs Compared)

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88 medications are used for Pain prophylaxis, with 508 combined adverse event reports. The most reported drugs for Pain prophylaxis are ACETAMINOPHEN and NEFOPAM.

508
Total Reports
88
Drugs Used

All Medications for Pain prophylaxis Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
ACETAMINOPHEN Hydrocodone Bitartrate and Acetaminophen 118 30,085 50,046 22.0%
NEFOPAM - 61 360 1,685 12.6%
IBUPROFEN equate ibuprofen 52 6,705 29,386 7.7%
NAPROXEN Naproxen Sodium 52 5,127 12,849 9.7%
TRAMADOL ConZip 37 14,555 19,235 19.2%
MORPHINE Morphine Sulfate 32 38,212 17,386 31.7%
KETOPROFEN Orudis 23 393 2,947 7.1%
FENTANYL FENTANYL 21 42,491 15,153 45.0%
DICLOFENAC Diclofenac Sodium Delayed Release 16 6,378 16,398 7.3%
OXYCODONE Oxycodone Hydrochloride 16 55,140 21,279 28.9%
GABAPENTIN Gabapentin 15 11,101 16,499 14.9%
LIDOCAINE Burn Relief 13 1,738 5,570 7.6%
SODIUM BICARBONATE QUABIC-100 11 783 1,665 24.5%
ALEVE CAPLET - 7 7 14 0.6%
DEXAMETHASONE Dexamethasone Sodium Phosphate 6 22,319 51,311 17.8%
HYDROMORPHONE Hydromorphone Hydrochloride 6 28,491 10,395 34.1%
LIDOCAINE\PRILOCAINE - 6 8 156 1.6%
ACETAMINOPHEN\CODEINE - 5 3,387 4,926 22.3%
ACETAMINOPHEN\HYDROCODONE - 5 31,727 6,901 29.1%
ACETAMINOPHEN\TRAMADOL - 5 573 2,486 10.3%

View all 88 drugs →

Most Reported Drugs for Pain prophylaxis

#1 most reported
#2 most reported
#3 most reported